Impact of epigenetics in aging and age related neurodegenerative diseases

被引:23
|
作者
Gangisetty, Omkaram [1 ]
Cabrera, Miguel A. [1 ]
Murugan, Sengottuvelan [1 ]
机构
[1] Rutgers State Univ, Dept Anim Sci, Endocrine Res Facil, 67 Poultry Farm Lane, New Brunswick, NJ 08901 USA
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2018年 / 23卷
关键词
Epigenetics; Aging; DNA methylation; Histone code; Micro RNA; Long non coding RNA; Neurodegenerative disease; Review; LONG NONCODING RNAS; ALPHA-SYNUCLEIN EXPRESSION; REPEAT KINASE 2; ALZHEIMERS-DISEASE; DNA-METHYLATION; PARKINSONS-DISEASE; GENE-EXPRESSION; HISTONE H3; PROMOTER METHYLATION; S-ADENOSYLMETHIONINE;
D O I
10.2741/4654
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epigenetics involves multiple processes such as DNA methylation, histone code modifications, and noncoding RNAs to regulate gene expression. In recent years the implications of epigenetic mechanisms have emerged in the field of neuroscience especially in brain development, memory, learning, and various cognition processes. Epigenetics also plays a pivotal role during the aging process of the brain which has led to various age-related neurodegenerative diseases. This manuscript portrays the findings of various epigenetic mechanisms that play a critical role and their implications in aging as well as age-related neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
引用
收藏
页码:1445 / 1464
页数:20
相关论文
共 50 条
  • [41] Mitochondrial epigenetics in aging and cardiovascular diseases
    Mongelli, Alessia
    Mengozzi, Alessandro
    Geiger, Martin
    Gorica, Era
    Mohammed, Shafeeq Ahmed
    Paneni, Francesco
    Ruschitzka, Frank
    Costantino, Sarah
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2023, 10
  • [42] The contribution of CNVs to the most common aging-related neurodegenerative diseases
    Giulia Gentile
    Valentina La Cognata
    Sebastiano Cavallaro
    Aging Clinical and Experimental Research, 2021, 33 : 1187 - 1195
  • [43] The contribution of CNVs to the most common aging-related neurodegenerative diseases
    Gentile, Giulia
    La Cognata, Valentina
    Cavallaro, Sebastiano
    AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2021, 33 (05) : 1187 - 1195
  • [44] Epigenetics of alcohol-related liver diseases
    Habash, Nawras W.
    Sehrawat, Tejasav S.
    Shah, Vijay H.
    Cao, Sheng
    JHEP REPORTS, 2022, 4 (05)
  • [45] The impact of base excision DNA repair in age-related neurodegenerative diseases
    Leandro, Giovana S.
    Sykora, Peter
    Bohr, Vilhelm A.
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2015, 776 : 31 - 39
  • [46] Symposium 4: Vitamins, infectious and chronic disease during adulthood and aging Nutritional influences on epigenetics and age-related disease
    Park, Lara K.
    Friso, Simonetta
    Choi, Sang-Woon
    PROCEEDINGS OF THE NUTRITION SOCIETY, 2012, 71 (01) : 75 - 83
  • [47] Role of Epigenetics in Stem Cell Proliferation and Differentiation: Implications for Treating Neurodegenerative Diseases
    Srinageshwar, Bhairavi
    Maiti, Panchanan
    Dunbar, Gary L.
    Rossignol, Julien
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (02)
  • [48] Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases
    Roubroeks, Janou A. Y.
    Smith, Rebecca G.
    van den Hove, Daniel L. A.
    Lunnon, Katie
    JOURNAL OF NEUROCHEMISTRY, 2017, 143 (02) : 158 - 170
  • [49] Epigenetics in Ocular Diseases
    Liu, Melissa M.
    Chan, Chi-Chao
    Tuo, Jingsheng
    CURRENT GENOMICS, 2013, 14 (03) : 166 - 172
  • [50] Epigenetics and vascular diseases
    Stratton, Matthew S.
    Farina, Floriana Maria
    Elia, Leonardo
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2019, 133 : 148 - 163