Impact of epigenetics in aging and age related neurodegenerative diseases

被引：23

作者：

Gangisetty, Omkaram ^{[1
]}

Cabrera, Miguel A. ^{[1
]}

Murugan, Sengottuvelan ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Anim Sci, Endocrine Res Facil, 67 Poultry Farm Lane, New Brunswick, NJ 08901 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2018年 / 23卷

关键词：

Epigenetics; Aging; DNA methylation; Histone code; Micro RNA; Long non coding RNA; Neurodegenerative disease; Review; LONG NONCODING RNAS; ALPHA-SYNUCLEIN EXPRESSION; REPEAT KINASE 2; ALZHEIMERS-DISEASE; DNA-METHYLATION; PARKINSONS-DISEASE; GENE-EXPRESSION; HISTONE H3; PROMOTER METHYLATION; S-ADENOSYLMETHIONINE;

D O I：

10.2741/4654

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epigenetics involves multiple processes such as DNA methylation, histone code modifications, and noncoding RNAs to regulate gene expression. In recent years the implications of epigenetic mechanisms have emerged in the field of neuroscience especially in brain development, memory, learning, and various cognition processes. Epigenetics also plays a pivotal role during the aging process of the brain which has led to various age-related neurodegenerative diseases. This manuscript portrays the findings of various epigenetic mechanisms that play a critical role and their implications in aging as well as age-related neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.

引用

页码：1445 / 1464

页数：20

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