Alcohol consumption and metabolic syndrome in the elderly: results from the Italian longitudinal study on aging

被引:39
作者
Buja, A. [1 ]
Scafato, E. [2 ]
Sergi, G. [3 ]
Maggi, S. [4 ]
Suhad, M. A. [1 ]
Rausa, G. [1 ]
Coin, A. [3 ]
Baldi, I. [5 ]
Manzato, E. [3 ]
Galluzzo, L. [2 ]
Enzi, G. [3 ]
Perissinotto, E. [1 ]
机构
[1] Univ Padua, Dept Environm Med & Publ Hlth, I-35128 Padua, Italy
[2] Ist Super Sanita, I-00161 Rome, Italy
[3] Univ Padua, Geriatr Unit, Dept Med & Surg Sci, I-35128 Padua, Italy
[4] CNR, Ist Neurosci, Padua, Italy
[5] S Giovanni Battista Hosp, Epidemiol Unit, Turin, Italy
关键词
drinking; metabolic syndrome; elderly; cohort; epidemiology; CORONARY-HEART-DISEASE; LIFE-STYLE FACTORS; NATIONAL-HEALTH; BLOOD-PRESSURE; RISK-FACTORS; PREVALENCE; ADULTS; METAANALYSIS; DRINKING; AGE;
D O I
10.1038/ejcn.2009.136
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background/Objectives: Although there is plenty of evidence of the association between metabolic syndrome ( MS) and cardiovascular disease, the relationship between alcohol consumption and MS is still questioned. The few publications with respect to the elderly seem to indicate that alcohol consumption is unassociated with MS. The aim of this study was to assess the association between alcohol consumption and the prevalence and incidence of MS, as well as its components in a large sample of Italian elderly people. Subjects/Methods: This is a multicenter study on a population-based sample of Italian people aged 65-84 years. The Italian Longitudinal Study on Aging (ILSA) included a prevalence phase in 1992 and an incidence phase from 1995 to 1996. The median length of follow-up was 3.5 years. In the present study, the analysis included 1321 men grouped into five alcohol consumption classes: abstainers, and those consuming <= 12, 13-24, 25-47 or >= 48 g of alcohol in a day. Among the 1122 women considered, the last two of the above five categories were pooled together ( 424 g/day). MS was defined according to ATP III criteria. All statistical analyses were stratified by gender. Results: Adjusted odds ratios showed that categorized alcohol consumption was not significantly associated with the prevalence and incidence of MS when compared with abstainers in either gender. For the MS incidence survey, three of five components (systolic pressure, glycemia and waist circumference) proved to be significantly and harmfully affected by alcohol consumption in males, whereas no such significant association emerged in females. Conclusions: These results suggest that alcohol can modify an individual's metabolic condition and that, even among the elderly, men might be more sensitive to the effects of alcohol than women. European Journal of Clinical Nutrition (2010) 64, 297-307; doi:10.1038/ejcn.2009.136; published online 25 November 2009
引用
收藏
页码:297 / 307
页数:11
相关论文
共 44 条
[31]   Low prevalence of the metabolic syndrome in wine drinkers -: is it the alcohol beverage or the lifestyle? [J].
Rosell, M ;
de Faire, U ;
Hellénius, ML .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2003, 57 (02) :227-234
[32]   Alcohol intake, smoking, sleeping hours, physical activity and the metabolic syndrome [J].
Santos, A.-C. ;
Ebrahim, S. ;
Barros, H. .
PREVENTIVE MEDICINE, 2007, 44 (04) :328-334
[33]   The metabolic syndrome in older individuals: Prevalence and prediction of cardiovascular events - The Cardiovascular Health Study [J].
Scuteri, A ;
Najjar, SS ;
Morrell, CH ;
Lakatta, EG .
DIABETES CARE, 2005, 28 (04) :882-887
[34]  
SOFFRIZZI V, 2007, NEUROLOGY, V68, P1790
[35]   Waist circumference in relation to history of amount and type of alcohol:: results from the Copenhagen City Heart Study [J].
Vadstrup, ES ;
Petersen, L ;
Sorensen, TIA ;
Gronbæk, M .
INTERNATIONAL JOURNAL OF OBESITY, 2003, 27 (02) :238-246
[36]   Effects of age on the relationship between drinking and atherosclerotic risk factors [J].
Wakabayashi, I ;
Kobaba-Wakabayashi, R .
GERONTOLOGY, 2002, 48 (03) :151-156
[37]   Age-dependent association of alcohol drinking with pulse pressure [J].
Wakabayashi, Ichiro .
JOURNAL OF HYPERTENSION, 2007, 25 (05) :971-975
[38]   Modifiable lifestyle factors and the metabolic syndrome in older men: Effects of lifestyle changes [J].
Wannamethee, S. Goya ;
Shaper, A. Gerald ;
Whincup, Peter H. .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2006, 54 (12) :1909-1914
[39]   Lifestyle factors and incident metabolic syndrome The Tromso Study 1979-2001 [J].
Wilsgaard, Tom ;
Jacobsen, Bjarne K. .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2007, 78 (02) :217-224
[40]   Sex is a major determinant of CYP3A4 expression in human liver [J].
Wolbold, R ;
Klein, K ;
Burk, O ;
Nüssler, AK ;
Neuhaus, P ;
Eichelbaum, M ;
Schwab, M ;
Zanger, UM .
HEPATOLOGY, 2003, 38 (04) :978-988