Oral administration of D-galactose induces cognitive impairments and oxidative damage in rats

被引：55

作者：

Budni, Josiane ^{[1
,2
]}

Pacheco, Robson ^{[1
,2
]}

da Silva, Sabrina ^{[1
,2
]}

Garcez, Michelle Lima ^{[1
,2
]}

Mina, Francielle ^{[1
,2
]}

Bellettini-Santos, Tatiani ^{[1
,2
]}

de Medeiros, Jesiel ^{[1
,2
]}

Voss, Bruna Constantino ^{[1
,2
]}

Steckert, Amanda Valnier ^{[1
]}

Valvassori, Samira da Silva ^{[1
,3
]}

Quevedo, Joao ^{[1
,4
,5
,6
]}

机构：

[1] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Lab Neurociencias, BR-88806000 Criciuma, SC, Brazil

[2] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Lab Doencas Neurodegenerat, BR-88806000 Criciuma, SC, Brazil

[3] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Programa Posgrad Ciencias Saude, Lab Sinalizacao Neural & Psicofarmacol, BR-88806000 Criciuma, SC, Brazil

[4] Univ Texas Hlth Sci Ctr Houston UTHlth, Dept Psychiat & Behav Sci, Translat Psychiat Program, McGovern Med Sch, Houston, TX USA

[5] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Ctr Excellence Mood Disorders, McGovern Med Sch, Houston, TX 77030 USA

[6] Univ Texas Hlth Sci Ctr Houston, Grad Sch Biomed Sci, Neurosci Grad Program, Houston, TX 77030 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2016年 / 302卷

关键词：

Oral D-galactose; Aging; Cognitive impairment; Oxidative damage; ALZHEIMERS-DISEASE; MITOCHONDRIAL DYSFUNCTION; BRAIN; STRESS; DEFICITS; MODEL; INJECTION; PROTEIN; MICE; HIPPOCAMPUS;

D O I：

10.1016/j.bbr.2015.12.041

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

D-Galactose (D-gal) is a reducing sugar that can be used to mimic the characteristics of aging in rodents; however, the effects of D-gal administration by oral route are not clear. Therefore, the aim of this study was to elucidate if the oral administration of D-gal induces cognitive impairments, neuronal loss, and oxidative damage, mimicking an animal model of aging. Male adult Wistar rats (4 months old) received D-gal (100 mg/kg) via the oral route for a period of 1, 2, 4, 6 or 8 weeks. The results showed cognitive impairments in the open-field test in the 4th and 6th weeks after D-gal administration, as well as an impairment in spatial memory in the radial maze test after the 6th week of D-gal administration. The results indicated increase of levels of thiobarbituric acid reactive species TBARS and carbonyl group content in the prefrontal cortex from the 4th week, and in all weeks of D-gal administration, respectively. An increase in the levels of TBARS and carbonyl group content was observed in the hippocampus over the entire period of D-gal treatment. In the 8th week of D-gal administration, we also observed reductions in synaptophysin and TAU protein levels in the prefrontal cortex. Thus, D-gal given by oral route caused cognitive impairments which were accompanied by oxidative damage. Therefore, these results indicate that orally administered D-gal can induce the behavioral and neurochemical alterations that are observed in the natural aging process. However, oral D-gal effect in rats deserve further studies to be better described. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：35 / 43

页数：9

共 62 条

[1]

Alcedo Joy, 2013, Frontiers in Genetics, V4, P71, DOI 10.3389/fgene.2013.00071

[2] Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model [J].