CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells

被引：6
作者：
Xu, Bing [1 ]
Chen, Hui [1 ]
Xu, Zhipeng [2 ]
Yao, Xijuan [1 ]
Sun, Xinchen [1 ]
Cheng, Hongyan [3 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China
[2] Southeast Univ, Affiliated Zhongda Hosp, Dept Urol, Nanjing 210009, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Synthet Internal Med, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2021年 / 24卷 / 01期
基金：
中国国家自然科学基金;
关键词：
tumorigenesis; radiosensitivity; The Cancer Genome Atlas; DNA repair; gene set enrichment analysis; cell cycle phase; CANCER-CELLS; DNA-REPAIR; CYCLE; SENSITIVITY; EXPRESSION; BIOMARKERS; CHROMATIN; GENES;
D O I：
10.3892/mmr.2021.12169
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cell division cycle-associated 2 (CDCA2) overexpression has been demonstrated to serve a significant role in tumorigenesis in certain types of cancer. Nevertheless, its role in tumour proliferation and radioresistance in oesophageal squamous cell carcinoma (ESCC) remains to be elucidated. Thus, the present study aimed to elucidate these roles. Data were downloaded from The Cancer Genome Atlas (TCGA) to compare the gene expression profiles. The expression of CDCA2 was higher in ESCC tissues compared with normal tissues. Gene set enrichment analysis was performed based on the ESCC cohorts in TCGA database. This demonstrated that higher expression of CDCA2 was significantly associated with the expression of related components of the cell cycle phase transition and G(2)/M phase transition pathways. Collectively, the results revealed that CDCA2 could serve as an underlying target to regulate tumour growth and radioresistance among patients with ESCC.
引用
收藏
页数：10
相关论文
共 34 条
  • [1] Delivery of Temozolomide and N3-Propargyl Analog to Brain Tumors Using an Apoferritin Nanocage
    Bouzinab, Kaouthar
    Summers, Helen S.
    Stevens, Malcolm F. G.
    Moody, Christopher J.
    Thomas, Neil R.
    Gershkovich, Pavel
    Weston, Nicola
    Ashford, Marianne B.
    Bradshaw, Tracey D.
    Turyanska, Lyudmila
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2020, 12 (11) : 12609 - 12617
  • [2] Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers
    Buckley, Amy M.
    Lynam-Lennon, Niamh
    O'Neill, Hazel
    O'Sullivan, Jacintha
    [J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2020, 17 (05) : 298 - 313
  • [3] PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways
    Chang, L.
    Graham, P. H.
    Hao, J.
    Ni, J.
    Bucci, J.
    Cozzi, P. J.
    Kearsley, J. H.
    Li, Y.
    [J]. CELL DEATH & DISEASE, 2014, 5 : e1437 - e1437
  • [4] Chemoradiation in oesophageal cancer
    Dai, Tong
    Shah, Manish A.
    [J]. BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2015, 29 (01) : 193 - 209
  • [5] Selective Targeting of the G2/M Cell Cycle Checkpoint to Improve the Therapeutic Index of Radiotherapy
    Dillon, M. T.
    Good, J. S.
    Harrington, K. J.
    [J]. CLINICAL ONCOLOGY, 2014, 26 (05) : 257 - 265
  • [6] CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo
    Feng, Yifei
    Qian, Wenwei
    Zhang, Yue
    Peng, Wen
    Li, Jie
    Gu, Qiou
    Ji, Dongjian
    Zhang, Zhiyuan
    Wang, Qingyuan
    Zhang, Dongsheng
    Sun, Yueming
    [J]. BMC CANCER, 2019, 19 (1)
  • [7] Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods
    Ferlay, J.
    Colombet, M.
    Soerjomataram, I.
    Mathers, C.
    Parkin, D. M.
    Pineros, M.
    Znaor, A.
    Bray, F.
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2019, 144 (08) : 1941 - 1953
  • [8] Silencing human epidermal growth factor receptor-3 radiosensitizes human luminal A breast cancer cells
    He, Guofeng
    Di, Xiaoke
    Yan, Jingjing
    Zhu, Caiqiang
    Sun, Xinchen
    Zhang, Shu
    [J]. CANCER SCIENCE, 2018, 109 (12): : 3774 - 3782
  • [9] Jemal A, 2011, CA-CANCER J CLIN, V61, P134, DOI [10.3322/caac.21492, 10.3322/caac.20115, 10.3322/caac.20107]
  • [10] Altered expression of cell cycle genes distinguishes aggressive neuroblastoma
    Krasnoselsky, AL
    Whiteford, CC
    Wei, JS
    Bilke, S
    Westermann, F
    Chen, QR
    Khan, J
    [J]. ONCOGENE, 2005, 24 (09) : 1533 - 1541
1234