Cytoskeletal requirements for hepatitis C virus (HCV) RNA synthesis in the HCV replicon cell culture system

被引：66
|
作者：
Bost, AG [1 ]
Venable, D [1 ]
Liu, L [1 ]
Heinz, BA [1 ]
机构：
[1] Lilly Corp Ctr, Eli Lilly & Co, Lilly Res Labs, Infect Dis Res, Indianapolis, IN 46285 USA
来源：
JOURNAL OF VIROLOGY | 2003年 / 77卷 / 07期
关键词：
D O I：
10.1128/JVI.77.7.4401-4408.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hepatitis C virus (HCV) induces microtubule aggregates in infected hepatocytes. To determine if cytoskelletall elements are important for HCV RNA synthesis, we examined the effect of cytoskeleton inhibitors on HCV replicon transcription in Huh7 cells. The data demonstrate that HCV replication complex-mediated RNA synthesis requires microtubule and actin polymerization.
引用
收藏
页码：4401 / 4408
页数：8
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