Ionic liquids-promoted multi-component reaction: Green approach for highly substituted 2-aminofuran derivatives

被引：33

作者：

Yadav, JS ^{[1
]}

Reddy, BVS ^{[1
]}

Shubashree, S ^{[1
]}

Sadashiv, K ^{[1
]}

Naidu, JJ ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2004年 / 14期

关键词：

ionic liquids (ILs); multi-component reaction; furan derivatives;

D O I：

10.1055/s-2004-831181

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The three-component coupling of aldehyde, dimethyl acetylenedicarboxylate (DMAD) and cyclohexyl isocyanide proceeds efficiently in [bmim]BF4 ionic medium under extremely mild conditions to afford the corresponding 2-aminofuran derivatives in high yields. The zwitterionic intermediate formed in situ from DMAD and isocyanide shows enhanced reactivity in ionic liquids, thereby reducing reaction times and improving the yields significantly. Ionic liquid helps to avoid the use of highly toxic and environmentally unfavorable benzene as solvent for this conversion. The recovered ionic liquid was reused for five to six times with consistent activity.

引用

页码：2376 / 2380

页数：5

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