Arsenic exposure during prepuberty alters prostate maturation in pubescent rats

被引：9
作者：
Aquino, Ariana M. [1 ]
Salata, Giovanna C. [1 ]
Pinho, Cristiane F. [1 ]
de Freitas, Andre T. A. G. [1 ]
Perico, Larissa L. [1 ]
Siervo, Glaucia E. M. de Lion [4 ]
Mendes, Leonardo O. [2 ]
De Medeiros, Paloma Da Cunha [3 ]
Justulin, Luis A. [1 ]
Fernandes, Glaura S. A. [4 ]
Perobelli, Juliana E. [3 ]
Scarano, Wellerson R. [1 ]
机构：
[1] Sao Paulo State Univ, Dept Morphol, UNESP, BR-18618689 Botucatu, SP, Brazil
[2] Univ Oeste Paulista, Grad Program Anim Sci, BR-19050920 Presidente Prudente, SP, Brazil
[3] Univ Fed Sao Paulo, Inst Mar IMAR, BR-11015020 Santos, Brazil
[4] Univ Estadual Londrina, Dept Gen Biol, BR-86057970 Londrina, Brazil
来源：
REPRODUCTIVE TOXICOLOGY | 2019年 / 89卷
关键词：
Prostate; Late morphogenesis; Puberty; Arsenic; Postnatal development; VENTRAL PROSTATE; DRINKING-WATER; PROTEINASE ACTIVITIES; OXIDATIVE STRESS; SODIUM ARSENITE; CANCER; INFLAMMATION; MECHANISMS; MICROENVIRONMENT; INTERLEUKIN-10;
D O I：
10.1016/j.reprotox.2019.07.010
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Arsenic is a widely dispersed chemical compound in the environment and has been associated with the development of some diseases and different types of cancer. Little is known about the action of arsenic compounds on prostate development during prepuberty and puberty. This study evaluated prostate morphophysiology after sodium arsenite exposure during prepubertal period in rats. Male Wistar rats at PND23 were randomly distributed into three experimental groups (n = 10/group). The Ctrl group (filtered drinking water); As1 group (0.01 mg/L of NaAsO2); As2 group (10.0 mg/L of NaAsO2) that received the diluted solution in drinking water from PND23 to PND53. Histological and molecular analyzes showed developmental delay in the As1 group and important morphophysiological alterations in As2 group. The results showed that exposure to NaAsO2 during prepuberty compromised structural and functional maturation of the prostate in pubertal rats at both doses evaluated in this study.
引用
收藏
页码：136 / 144
页数：9
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