Arsenic exposure during prepuberty alters prostate maturation in pubescent rats

被引：9

作者：

Aquino, Ariana M. ^{[1
]}

Salata, Giovanna C. ^{[1
]}

Pinho, Cristiane F. ^{[1
]}

de Freitas, Andre T. A. G. ^{[1
]}

Perico, Larissa L. ^{[1
]}

Siervo, Glaucia E. M. de Lion ^{[4
]}

Mendes, Leonardo O. ^{[2
]}

De Medeiros, Paloma Da Cunha ^{[3
]}

Justulin, Luis A. ^{[1
]}

Fernandes, Glaura S. A. ^{[4
]}

Perobelli, Juliana E. ^{[3
]}

Scarano, Wellerson R. ^{[1
]}

机构：

[1] Sao Paulo State Univ, Dept Morphol, UNESP, BR-18618689 Botucatu, SP, Brazil

[2] Univ Oeste Paulista, Grad Program Anim Sci, BR-19050920 Presidente Prudente, SP, Brazil

[3] Univ Fed Sao Paulo, Inst Mar IMAR, BR-11015020 Santos, Brazil

[4] Univ Estadual Londrina, Dept Gen Biol, BR-86057970 Londrina, Brazil

来源：

REPRODUCTIVE TOXICOLOGY | 2019年 / 89卷

关键词：

Prostate; Late morphogenesis; Puberty; Arsenic; Postnatal development; VENTRAL PROSTATE; DRINKING-WATER; PROTEINASE ACTIVITIES; OXIDATIVE STRESS; SODIUM ARSENITE; CANCER; INFLAMMATION; MECHANISMS; MICROENVIRONMENT; INTERLEUKIN-10;

D O I：

10.1016/j.reprotox.2019.07.010

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Arsenic is a widely dispersed chemical compound in the environment and has been associated with the development of some diseases and different types of cancer. Little is known about the action of arsenic compounds on prostate development during prepuberty and puberty. This study evaluated prostate morphophysiology after sodium arsenite exposure during prepubertal period in rats. Male Wistar rats at PND23 were randomly distributed into three experimental groups (n = 10/group). The Ctrl group (filtered drinking water); As1 group (0.01 mg/L of NaAsO2); As2 group (10.0 mg/L of NaAsO2) that received the diluted solution in drinking water from PND23 to PND53. Histological and molecular analyzes showed developmental delay in the As1 group and important morphophysiological alterations in As2 group. The results showed that exposure to NaAsO2 during prepuberty compromised structural and functional maturation of the prostate in pubertal rats at both doses evaluated in this study.

引用

页码：136 / 144

页数：9

共 50 条

[21] Behavioral and general effects of subacute oral arsenic exposure in rats with and without fluoride [J].

Sarkoezi, Kitti ;

Horvath, Edina ;

Vezer, Tuende ;

Papp, Andras ;

Paulik, Edit .

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH, 2015, 25 (04) :418-431

[22] In Utero Exposure to TCDD Alters Wnt Signaling During Mouse Prostate Development: Linking Ventral Prostate Agenesis to Downregulated β-Catenin Signaling [J].

Schneider, Andrew J. ;

Moore, Robert W. ;

Branam, Amanda M. ;

Abler, Lisa L. ;

Keil, Kimberly P. ;

Mehta, Vatsal ;

Vezina, Chad M. ;

Peterson, Richard E. .

TOXICOLOGICAL SCIENCES, 2014, 141 (01) :176-187

[23] Exposure to mixtures of mercury, cadmium, lead, and arsenic alters the disposition of single metals in tissues of Wistar rats [J].

Orr, Sarah E. ;

Barnes, Mary C. ;

George, Hannah S. ;

Joshee, Lucy ;

Jeon, Byunggwon ;

Scircle, Austin ;

Black, Oscar ;

Cizdziel, James V. ;

Smith, Betsy E. ;

Bridges, Christy C. .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2018, 81 (24) :1246-1256

[24] Long-term effects of perinatal exposure to low doses of cadmium on the prostate of adult male rats [J].

Santana, Viviane P. ;

Salles, Evila S. ;

Correa, Deborah E. ;

Goncalves, Bianca F. ;

Campos, Silvana G. ;

Justulin, Luiz A. ;

Godinho, Antonio F. ;

Scarano, Wellerson R. .

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 2016, 97 (04) :310-316

[25] Exposure to aluminium chloride during the peripuberal period induces prostate damage in male rats [J].

Leal, Franciely A. V. D. ;

Goncalves, Gessica D. ;

Soncini, Joao Gabriel M. ;

Staurengo-Ferrari, Larissa A. ;

Fattori, Victor R. ;

Verri, Waldiceu A., Jr. ;

Scarano, Wellerson R. ;

Fernandes, Glaura S. A. .

ACTA HISTOCHEMICA, 2022, 124 (01)

[26] Arsenic exposure alters expression of cell cycle and lipid metabolism genes in the liver of adult zebrafish (Danio rerio) [J].

Carlson, Patrick ;

Van Beneden, Rebecca J. .

AQUATIC TOXICOLOGY, 2014, 153 :66-72

[27] Transplacental and early life exposure to inorganic arsenic affected development and behavior in offspring rats [J].

Xi, Shuhua ;

Sun, Wenjuan ;

Wang, Fengzhi ;

Jin, Yaping ;

Sun, Guifan .

ARCHIVES OF TOXICOLOGY, 2009, 83 (06) :549-556

[28] Hematological effects of arsenic in rats after subchronical exposure during pregnancy and lactation: The protective role of antioxidants [J].

Antonio Garcia, Maria Teresa ;

Herrera Duenas, Amparo ;

Pineda Pampliega, Javier .

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2013, 65 (05) :609-614

[29] Prenatal arsenite exposure alters maternal cardiac remodeling during late pregnancy [J].

Taube, Nicole ;

Kabir, Raihan ;

V. Ebenebe, Obialunanma ;

Garbus, Haley ;

El Din, Sarah -Marie Alam ;

Illingworth, Emily ;

Fitch, Michael ;

Wang, Nadan ;

Kohr, Mark J. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2024, 483

[30] Concomitant exposure to arsenic and organophosphates on tissue oxidative stress in rats [J].

Dwivedi, Nidhi ;

Flora, Swaran J. S. .

FOOD AND CHEMICAL TOXICOLOGY, 2011, 49 (05) :1152-1159

← 1 2 3 4 5 →