The Risk of Intracranial Hemorrhage in Japanese Patients with Acute Large Vessel Occlusion; subanalysis of the RESCUE-Japan registry

被引：18

作者：

Enomoto, Yukiko ^{[1
]}

Yoshimura, Shinichi ^{[2
]}

Egashira, Yusuke ^{[1
]}

Yamagami, Hiroshi ^{[3
]}

Sakai, Nobuyuki ^{[4
]}

机构：

[1] Gifu Univ, Dept Neurosurg, Grad Sch Med, 1-1 Yanagido, Gifu 5011194, Japan

[2] Hyogo Coll Med, Dept Neurosurg, Nishinomiya, Hyogo, Japan

[3] Natl Cerebral & Cardiovasc Ctr, Dept Cerebrovasc Med, Osaka, Japan

[4] Kobe City Med Ctr, Dept Neurosurg, Kobe, Hyogo, Japan

来源：

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2016年 / 25卷 / 05期

关键词：

Acute stroke; recanalization therapy; endovascular; intracranial hemorrhage; ACUTE ISCHEMIC-STROKE; ENDOVASCULAR TREATMENT; PLASMINOGEN-ACTIVATOR; RANDOMIZED-TRIAL; POOLED ANALYSIS; THROMBECTOMY; MERCI; RETRIEVER; ALTEPLASE; EFFICACY;

D O I：

10.1016/j.jstrokecerebrovasdis.2015.12.022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Recanalization therapies such as intravenous thrombolysis (IVT) or endovascular treatment (EVT) improve acute ischemic stroke outcomes; however, they carry the risk of intracranial hemorrhage (ICH). The present study assessed the frequency and predictive factor of ICH in Japanese patients with acute large vessel occlusion. Methods: The Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism-Japan Registry prospectively registered 1442 stroke patients with major vessel occlusion who were admitted to 84 Japanese stroke centers within 24 hours after onset, from July 2010 to June 2011. Among these 1442 patients, 1357 were included to evaluate the incidence rate and predictive factors of ICH within 24 hours after onset. Results: ICH was observed in 284 (20.9%) patients. Among these patients, 46 (3.4%) had symptomatic ICH, and its incidence was higher in the recanalization therapy (IVT and/or EVT) group than in the conservative therapy group (4.5% versus 2.1%, P=.013). On multivariate analyses, symptomatic ICH was related to pretreatment antiplatelet agent use and systemic heparinization, and was related to neither IVT nor EVT. Conclusions: Symptomatic ICH was not affected by recanalization therapy or EVT itself in Japanese patients with acute large vessel occlusion.

引用

页码：1076 / 1080

页数：5

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