Clinical study on gastrointestinal stromal tumors (GIST) in Iceland, 1990-2003

被引:36
作者
Tryggvason, Geir
Kristmundsson, Porarinn [1 ]
Oervar, Kjartan
Jonasson, Jon G.
Magnusson, Magnus K.
Gislason, HJoertur G.
机构
[1] Landspitali Univ Hosp, Dept Surg, IS-101 Reykjavik, Iceland
[2] Landspitali Univ Hosp, Dept Pathol, Reykjavik, Iceland
[3] Landspitali Univ Hosp, Dept Heamtol Genet & Mol Med, Reykjavik, Iceland
[4] St Josephs Hosp, Dept Med, Hafnarfjordur, Iceland
[5] Univ Iceland, Iceland Canc Registry, Iceland Canc Soc, Reykjavik, Iceland
[6] Univ Iceland, Fac Med, Reykjavik, Iceland
关键词
gastrointestinal stromal tumors; symptoms; prognosis;
D O I
10.1007/s10620-006-9248-4
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
This is a whole population-based study on clinical symptoms, surgical treatment, and outcome of GIST. All mesenchymal tumors in the digestive tract diagnosed from 1990 to 2003 were identified. All reports were reviewed, all tumors were stained with antibodies to c-kit, and the diagnosis of GIST was confirmed. Clinical, pathological, treatment, and outcome data were analyzed. The study included 53 patients with GIST. The mean age at diagnosis was 65.8 +/- 13.6 years (SD). Tumor distribution included 62% in the upper, 32% in the middle, and 6% in the lower digestive tract. Mean tumor size was 4.9 +/- 4.4 cm (SD). Gastrointestinal (GI) bleeding was the main symptom in 53% (20/38) of symptomatic cases; most presented with acute gastrointestinal bleeding. Complete surgical resection was performed in 87% (46/53) of patients. Eight of the 53 tumors (15.1%) metastasized, 7 of which were nongastric. The disease-specific death rate at 5 years was 85%, and 5-year survival after complete resection was 64.1%. We conclude that GISTs are often found incidentally but GI bleeding is the most common presentation. Five-year survival is better than previously reported and gastric GIST seems to be more benign than nongastric. GIST seems to metastasize mainly intra-abdominally.
引用
收藏
页码:2249 / 2253
页数:5
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