The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint?

被引：69
作者：
Jares, P [1 ]
Donaldson, A [1 ]
Blow, JJ [1 ]
机构：
[1] Univ Dundee, Dept Biochem, Div Gene REgulat & Express, CRC Chromosome Replicat Res Grp, Dundee DD1 5EH, Scotland
来源：
EMBO REPORTS | 2000年 / 1卷 / 04期
关键词：
D O I：
10.1093/embo-reports/kvd076
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cdc7/Dbf4 is a protein kinase that is required for the initiation of DNA replication in eukaryotes. Recent work has provided new clues to the role that Cdc7/Dbf4 plays in this process. A range of other observations suggest that Cdc7/Dbf4 also plays another, less well characterized, role in checkpoint function and in the maintenance of genomic integrity. In this review we attempt to bring together new information to explain how Cdc7/Dbf4 may perform these two distinct functions. © 2000 European Molecular Biology Organization.
引用
收藏
页码：319 / 322
页数：4
相关论文
共 39 条
  • [21] Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis
    Lei, M
    Kawasaki, Y
    Young, MR
    Kihara, M
    Sugino, A
    Tye, BK
    [J]. GENES & DEVELOPMENT, 1997, 11 (24) : 3365 - 3374
  • [22] Human Cdc7-related kinase complex -: In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a critical threonine residue of Cdc7 by Cdks
    Masai, H
    Matsui, E
    You, ZY
    Ishimi, Y
    Tamai, K
    Arai, K
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (37) : 29042 - 29052
  • [23] A KINASE FROM FISSION YEAST RESPONSIBLE FOR BLOCKING MITOSIS IN S-PHASE
    MURAKAMI, H
    OKAYAMA, H
    [J]. NATURE, 1995, 374 (6525) : 817 - 819
  • [24] Hierarchy of S-phase-promoting factors:: Yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin-dependent kinase activation
    Nougarède, R
    Della Seta, F
    Zarzov, P
    Schwob, E
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (11) : 3795 - 3806
  • [25] Oshiro G, 1999, MOL CELL BIOL, V19, P4888
  • [26] A role for the Cdc7 kinase regulatory subunit Dbf4p in the formation of initiation-competent origins of replication
    Pasero, P
    Duncker, BP
    Schwob, E
    Gasser, SM
    [J]. GENES & DEVELOPMENT, 1999, 13 (16) : 2159 - 2176
  • [27] Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase
    Pellicioli, A
    Lucca, C
    Liberi, G
    Marini, F
    Lopes, M
    Plevani, P
    Romano, A
    Di Fiore, PP
    Foiani, M
    [J]. EMBO JOURNAL, 1999, 18 (22) : 6561 - 6572
  • [28] DNA replication in vertebrates requires a homolog of the Cdc7 protein kinase
    Roberts, BT
    Ying, CY
    Gautier, J
    Maller, JL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) : 2800 - 2804
  • [29] Human and Xenopus cDNA encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7
    Sato, N
    Arai, K
    Masai, H
    [J]. EMBO JOURNAL, 1997, 16 (14) : 4340 - 4351
  • [30] Sclafani RA, 2000, J CELL SCI, V113, P2111
1234