Pulsatile Flow Leads to Intimal Flap Motion and Flow Reversal in an In Vitro Model of Type B Aortic Dissection

被引:27
作者
Birjiniuk, Joav [1 ,9 ]
Timmins, Lucas H. [2 ]
Young, Mark [3 ]
Leshnower, Bradley G. [4 ]
Oshinski, John N. [1 ,5 ]
Ku, David N. [6 ,7 ]
Veeraswamy, Ravi K. [8 ]
机构
[1] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, 315 Ferst Dr, Atlanta, GA 30332 USA
[2] Univ Utah, Dept Bioengn, 36 South Wasatch Dr, Salt Lake City, UT 84112 USA
[3] Medtronic Inc, Cardiac & Vasc Grp, 3576 Unocal Pl, Santa Rosa, CA 95403 USA
[4] Emory Univ, Div Cardiothorac Surg, Joseph B Whitehead Dept Surg, Sch Med, 1365 Clifton Rd, Atlanta, GA 30322 USA
[5] Emory Univ, Dept Radiol & Imaging Sci, Sch Med, 1364 Clifton Rd NE Suite D112, Atlanta, GA 30322 USA
[6] Georgia Inst Technol, George W Woodruff Sch Mech Engn, 315 Ferst Dr, Atlanta, GA 30332 USA
[7] Emory Univ, Div Vasc Surg, Joseph B Whitehead Dept Surg, Sch Med, 1365 Clifton Rd, Atlanta, GA 30322 USA
[8] Med Univ South Carolina, Div Vasc Surg, Dept Surg, 114 Doughty St Suite BM 654 MSC 295, Charleston, SC 29425 USA
[9] Emory Univ, Sch Med, 1648 Pierce Dr NE, Atlanta, GA 30307 USA
关键词
4D PCMR; Aortic dissection; Flow model; Hemodynamics; Intimal flap motion; SHEAR-STRESS; FALSE LUMEN; ENDOTHELIAL-CELLS; ABDOMINAL-AORTA; TEAR SIZE; ATHEROSCLEROSIS; LOCATION; PRESSURE; PATTERNS; VELOCITY;
D O I
10.1007/s13239-017-0312-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Understanding of the hemodynamics of Type B aortic dissection may improve outcomes by informing upon patient selection, device design, and deployment strategies. This project characterized changes to aortic hemodynamics as the result of dissection. We hypothesized that dissection would lead to elevated flow reversal and disrupted pulsatile flow patterns in the aorta that can be detected and quantified by non-invasive magnetic resonance imaging. Flexible, anatomic models of both normal aorta and dissected aorta, with a mobile intimal flap containing entry and exit tears, were perfused with a physiologic pulsatile waveform. Four-dimensional phase contrast magnetic resonance (4D PCMR) imaging was used to measure the hemodynamics. These images were processed to quantify pulsatile fluid velocities, flow rate, and flow reversal. Four-dimensional flow imaging in the dissected aorta revealed pockets of reverse flow and vortices primarily in the false lumen. The dissected aorta exhibited significantly greater flow reversal in the proximal-to-mid dissection as compared to normal (21.1 +/- 3.8 vs. 1.98 +/- 0.4%, p < 0.001). Pulsatility induced unsteady vortices and a pumping motion of the distal intimal flap corresponding to flow reversal. Summed true and false lumen flow rates in dissected models (4.0 +/- 2.0 L/min) equaled normal flow rates (3.8 +/- 0.1 L/min, p > 0.05), validated against external flow measurement. Pulsatile aortic hemodynamics in the presence of an anatomic, elastic dissection differed significantly from those of both steady flow through a dissection and pulsatile flow through a normal aorta. New hemodynamic features including flow reversal, large exit tear vortices, and pumping action of the mobile intimal flap, were observed. False lumen flow reversal would possess a time-averaged velocity close to stagnation, which may induce future thrombosis. Focal vortices may identify the location of tears that could be covered with a stent-graft. Future correlation of hemodynamics with outcomes may indicate which patients require earlier intervention.
引用
收藏
页码:378 / 389
页数:12
相关论文
共 40 条
[1]  
Ahrens J., 2005, VISUALIZATION HDB, P717, DOI [DOI 10.1016/B978-012387582-2/50038-1, 10.1016/B978-012387582-2/50038-1]
[2]   Effects of the patent false lumen on the long-term outcome Iq of type B acute aortic dissection [J].
Akutsu, K ;
Nejima, J ;
Kiuchi, K ;
Sasaki, K ;
Ochi, M ;
Tanaka, K ;
Takano, T .
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2004, 26 (02) :359-366
[3]   Aortic dissection simulation models for clinical support: fluid-structure interaction vs. rigid wall models [J].
Alimohammadi, Mona ;
Sherwood, Joseph M. ;
Karimpour, Morad ;
Agu, Obiekezie ;
Balabani, Stavroula ;
Diaz-Zuccarini, Vanessa .
BIOMEDICAL ENGINEERING ONLINE, 2015, 14
[4]   Development and testing of a silicone in vitro model of descending aortic dissection [J].
Birjiniuk, Joav ;
Ruddy, Jean Marie ;
Iffrig, Elizabeth ;
Henry, Travis S. ;
Leshnower, Bradley G. ;
Oshinski, John N. ;
Ku, David N. ;
Veeraswamy, Ravi K. .
JOURNAL OF SURGICAL RESEARCH, 2015, 198 (02) :502-507
[5]   Role of hemodynamic shear stress in cardiovascular disease [J].
Cecchi, Emanuele ;
Giglioli, Cristina ;
Valente, Serafina ;
Lazzeri, Chiara ;
Gensini, Gian Franco ;
Abbate, Rosanna ;
Mannini, Lucia .
ATHEROSCLEROSIS, 2011, 214 (02) :249-256
[6]   Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling - Molecular, cellular, and vascular behavior [J].
Chatzizisis, Yiannis S. ;
Coskun, Ahmet Umit ;
Jonas, Michael ;
Edelman, Elazer R. ;
Feldman, Charles L. ;
Stone, Peter H. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (25) :2379-2393
[7]   A patient-specific study of type-B aortic dissection: evaluation of true-false lumen blood exchange [J].
Chen, Duanduan ;
Mueller-Eschner, Matthias ;
von Tengg-Kobligk, Hendrik ;
Barber, David ;
Boeckler, Dittmar ;
Hose, Rod ;
Ventikos, Yiannis .
BIOMEDICAL ENGINEERING ONLINE, 2013, 12
[8]   Geometric and Flow Features of Type B Aortic Dissection: Initial Findings and Comparison of Medically Treated and Stented Cases [J].
Cheng, Zhuo ;
Wood, Nigel B. ;
Gibbs, Richard G. J. ;
Xu, Xiao Y. .
ANNALS OF BIOMEDICAL ENGINEERING, 2015, 43 (01) :177-189
[9]   True-lumen collapse in aortic dissection - Part I. Evaluation of causative factors in phantoms with pulsatile flow [J].
Chung, JW ;
Elkins, C ;
Sakai, T ;
Kato, N ;
Vestring, T ;
Semba, CP ;
Slonim, SM ;
Dake, MD .
RADIOLOGY, 2000, 214 (01) :87-98
[10]   A new imaging method for assessment of aortic dissection using four-dimensional phase contrast magnetic resonance imaging [J].
Clough, Rachel E. ;
Waltham, Matthew ;
Giese, Daniel ;
Taylor, Peter R. ;
Schaeffter, Tobias .
JOURNAL OF VASCULAR SURGERY, 2012, 55 (04) :914-923