Macular fibrosis in Coats' disease demonstrated by Optical Coherence Tomography Angiography - new data toward pathophysiology

被引：2

作者：

Chwiejczak, Katarzyna ^{[1
,2
,3
]}

Biswas, Susmito ^{[1
,2
,3
,4
]}

Tsamis, Emmanouil ^{[1
,2
,3
]}

Siso-Fuertes, Irene ^{[1
,2
,3
]}

Kasbia, Shakti ^{[1
,2
,3
]}

Stanga, Paulo E. ^{[1
,2
,3
,5
]}

机构：

[1] Manchester Univ Hosp NHS Fdn Trust, Manchester Royal Eye Hosp, Manchester Vis Regenerat MVR Lab, Manchester, Lancs, England

[2] Manchester Univ Hosp NHS Fdn Trust, NIHR Wellcome Trust Manchester CRF, Manchester, Lancs, England

[3] Manchester Univ Hosp NHS Fdn Trust, Manchester Royal Eye Hosp, Manchester, Lancs, England

[4] Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Div Evolut & Genom Sci, Manchester, Lancs, England

[5] London Vis Clin Retina, London, England

来源：

EUROPEAN JOURNAL OF OPHTHALMOLOGY | 2021年 / 31卷 / 06期

关键词：

Coats' disease; OCT angiography; macular fibrosis; retinal angiomatous proliferations; neovascularization; ENDOTHELIAL GROWTH-FACTOR; CHOROIDAL NEOVASCULARIZATION; TYPE-3; NEOVASCULARIZATION; SUBFOVEAL NODULE; CLASSIFICATION;

D O I：

10.1177/1120672120986366

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To analyze if Segmented Swept-Source Optical Coherence Tomography Angiography (SS OCT-A) can provide additional information on morphology and pathophysiology of macular fibrosis in Coats' patients. Methods: A consecutive case series of three male patients (5, 7 and 15 years old), with Coats' disease-related macular fibrosis (stage 2b-2 patients, 3b-1 patient). SS OCT-A 3x3 mm macular scans of affected eyes were performed. Results: In all three cases the inner portion of macular fibrosis displayed a dense network of vessels, continuing into deeper layers. This structure was similar to that observed in retinal angiomatous proliferations (RAP). There was associated loss of the foveal avascular zone. In one case we observed evolution of the lesion. Conclusion: SS-OCT imaging of macular fibrosis in Coats' disease reveals a distinct intralesional vascular structure with elements resembling RAP, probably developing as a secondary process.

引用

页码：3157 / 3163

页数：7

共 28 条

[1]

Coats G., 1908, Roy Lond Ophthalmol Hosp Rep, V17, P440

[2] OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VERSUS TRADITIONAL MULTIMODAL IMAGING IN ASSESSING THE ACTIVITY OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION A New Diagnostic Challenge [J].