Exploration of biocompatible AIEgens from natural resources

被引：223

作者：

Gu, Yuan ^{[1
,2
,3
]}

Zhao, Zheng ^{[1
,2
,3
]}

Su, Huifang ^{[1
,2
,3
]}

Zhang, Pengfei ^{[1
,2
,3
]}

Liu, Junkai ^{[4
]}

Niu, Guangle ^{[1
,2
,3
]}

Li, Shiwu ^{[4
]}

Wang, Zhaoyang ^{[5
]}

Kwok, Ryan T. K. ^{[1
,2
,3
]}

Ni, Xin-Long ^{[6
]}

Sun, Jingzhi ^{[5
]}

Qin, Anjun ^{[4
]}

Lam, Jacky W. Y. ^{[1
,2
,3
]}

Tang, Ben Zhong ^{[1
,2
,3
,4
,5
]}

机构：

[1] HKUST, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem & Biol Engn,Div Biomed Engn, Inst Adv Study,Dept Chem,Hong Kong Branch,Div Lif, Kowloon, Hong Kong, Peoples R China

[2] HKUST, State Key Lab Mol Neurosci, Kowloon, Hong Kong, Peoples R China

[3] HKUST, Shenzhen Res Inst, 9 Yuexing 1st RD,South Area Hitech Pk, Shenzhen 518057, Peoples R China

[4] South China Univ Technol, State Key Lab Luminescent Mat & Devices, SCUT HKUST Joint Res Lab, NSFC Ctr Luminescence Mol Aggregate, Guangzhou 510640, Guangdong, Peoples R China

[5] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China

[6] Guizhou Univ, MOE Key Lab Macrocycl & Supramol Chem Guizhou Pro, Guiyang 550025, Guizhou, Peoples R China

来源：

CHEMICAL SCIENCE | 2018年 / 9卷 / 31期

基金：

中国国家自然科学基金;

关键词：

AGGREGATION-INDUCED EMISSION; NAPHTHALENE DIIMIDE; BERBERINE CHLORIDE; LIVING CELLS; AIE; DERIVATIVES; THERAPY; COMPLEX; DESIGN; LIGHT;

D O I：

10.1039/c8sc01635f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Luminogens with aggregation-induced emission (AIEgens) characteristics have been well developed and applied in various areas such as bio-imaging, theranostics, organic photoelectronics and chemo/bio sensors. However, most of the reported AIEgens suffer from the disadvantages of complex organic synthesis and high cost, as well as being environmentally unfriendly and hard to degrade, which have largely limited their real applications. In this work, we discovered berberine chloride, a natural isoquinoline alkaloid isolated from Chinese herbal plants, as an unconventional rotor-free AIEgen with bright solid-state emission and water-soluble characteristics. Single crystal structure analysis and optical property, viscosity, and host-guest interaction studies suggested that intramolecular vibration and twisted intramolecular charge transfer were responsible for the AIE phenomenon of berberine chloride. Moreover, berberine chloride was biocompatible and could specifically target lipid droplets in a fluorescence turn-on and wash-free manner, demonstrating the great potential of natural products as promising AIE probes.

引用

页码：6497 / 6502

页数：6

共 45 条

[1] Artemisinin, a novel antimalarial drug: Biochemical and molecular approaches for enhanced production [J].