Functional switching of GABAergic synapses by ryanodine receptor activation

被引：17

作者：

Sun, MK ^{[1
]}

Nelson, TJ ^{[1
]}

Alkon, DL ^{[1
]}

机构：

[1] NINDS, Lab Adapt Syst, NIH, Bethesda, MD 20892 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 22期

关键词：

D O I：

10.1073/pnas.210396697

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The role of the ryanodine receptor (RyR) in modifiability of synapses made by the basket interneurons onto the hippocampal CA1 pyramidal cells was examined in rats. Associating single-cell RyR activation with postsynaptic depolarization increased intracellular free Ca2+ concentrations and reversed the basket interneuron-CA1 inhibitory postsynaptic potential into an excitatory postsynaptic potential. This synaptic transformation was accompanied by a shift of the reversal potential from that of chloride toward that of bicarbonate, This inhibitory postsynaptic potential-excitatory postsynaptic potential transformation was prevented by blocking RyR or carbonic anhydrase. Associated postsynaptic depolarization and RyR activation, therefore, changes GABAergic synapses from excitation filters to amplifier and, thereby, shapes information flow through the hippocampal network.

引用

页码：12300 / 12305

页数：6

共 47 条

[1] Time domains of neuronal Ca2+ signaling and associative memory:: steps through a calexcitin, ryanodine receptor, K+ channel cascade [J].