The Profiles and Correlates of Psychopathology in Adolescents and Adults with Williams, Fragile X and Prader-Willi Syndromes

被引：6
作者：
Royston, R. [1 ,5 ]
Oliver, C. [1 ]
Howlin, P. [2 ]
Dosse, A. [1 ]
Armitage, P. [1 ]
Moss, J. [1 ,3 ]
Waite, J. [1 ,4 ]
机构：
[1] Univ Birmingham, Sch Psychol, Cerebra Ctr Neurodev Disorders, Birmingham B15 2TT, W Midlands, England
[2] Kings Coll London, Dept Psychol, London WC2R 2LS, England
[3] UCL, Inst Cognit Neurosci, Alexandra House,17 Queen Sq, London WC1N 3AZ, England
[4] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England
[5] UCL, Div Psychiat, London W1T 7NF, England
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2020年 / 50卷 / 03期
关键词：
Williams syndrome; Prader-Willi syndrome; Fragile X syndrome; Psychopathology; Correlates; EMOTIONAL DISTURBANCE; PSYCHIATRIC-DISORDERS; MALADAPTIVE BEHAVIOR; ANXIETY DISORDERS; SOCIAL ANXIETY; CHILDREN; AUTISM; PREVALENCE; DIAGNOSIS; SYMPTOMS;
D O I：
10.1007/s10803-019-04317-1
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Psychopathology is prevalent in Williams (WS), fragile X (FXS) and Prader-Willi (PWS) syndromes. However, little is known about the potential correlates of psychopathology in these groups. A questionnaire study was completed by 111 caregivers of individuals with WS (n = 35); FXS (n = 50) and PWS (n = 26). Mean age was 26 years (range 12-57 years); 74 (67%) were male. Multiple regression analyses indicated that higher rates of health problems and sensory impairments predicted higher psychopathology in WS (p < .0001). In PWS, poorer adaptive ability predicted higher overall psychiatric disturbance (p = .001), generalised anxiety (p = .006) and hyperactivity (p = .003). There were no significant predictors in FXS. This study highlights dissociations in the potential risk markers of psychopathology between genetic syndromes. Implications for intervention are discussed.
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收藏
页码：893 / 903
页数：11
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