Physical linkage of the human growth hormone gene cluster and the CD79b (lgβ/B29) gene

被引：35
作者：
Bennani-Baïti, IM
Cooke, NE
Liebhaber, SA
机构：
[1] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA
来源：
GENOMICS | 1998年 / 48卷 / 02期
关键词：
D O I：
10.1006/geno.1997.5171
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We have previously characterized a locus control region for the GH1 gene consisting of four DNase I hypersensitive sites (HS) located between 14.5 and 32 kb 5' to the GH1 gene transcription start site, Sequence analysis of the region between the GH1 gene and its most proximal HS (HSI) revealed a perfect match to the B-lymphocyte-specific CD79b gene. Restriction mapping and hybridization analysis of YAC and cosmid clones confirmed the close linkage of the CD79b gene to the hGH gene cluster and facilitated the assembly of a 100-kb physical snap linking the hGH locus, the CD79b gene, and the more distant muscle-specific sodium channel alpha-subunit (SCN4A) gene. (C) 1998 Academic Press.
引用
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页码：258 / 264
页数：7
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