NSAID-gastroenteropathy: new aspects of pathogenesis and prevention

被引：51
作者：
Blackler, Rory W. [1 ]
Gemici, Burcu [2 ]
Manko, Anna [1 ]
Wallace, John L. [3 ,4 ]
机构：
[1] McMaster Univ, Dept Med, Hamilton, ON, Canada
[2] Near East Univ, Nicosia, Cyprus
[3] Univ Calgary, Dept Physiol & Pharmacol, Calgary, AB, Canada
[4] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada
来源：
CURRENT OPINION IN PHARMACOLOGY | 2014年 / 19卷
基金：
加拿大健康研究院;
关键词：
SMALL-INTESTINAL INJURY; PROTON PUMP INHIBITORS; HYDROGEN-SULFIDE; SMALL-BOWEL; BILE; ENTEROPATHY; INDOMETHACIN; BACTERIA; LESIONS; RATS;
D O I：
10.1016/j.coph.2014.05.008
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nonsteroidal anti-inflammatory drugs (NSAIDs) remain among the most commonly used medications because of their effectiveness in reducing pain and inflammation. Inhibitors of gastric acid secretion can substantially reduce the damaging effects of NSAIDs in the stomach and duodenum. However, there are no proven effective preventative or curative treatments for NSAID-induced enteropathy. In recent years, substantial progress has been made in better understanding the pathogenesis of NSAID-enteropathy, and in particular the interplay of enteric bacteria, bile and the enterohepatic recirculation of the NSAIDs. Moreover, it is becoming clear that suppression of gastric acid secretion significantly worsens NSAID-enteropathy.
引用
收藏
页码：11 / 16
页数：6
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