Reply to 'F508del-CFTR is not corrected by thymosin α1'

被引：2

作者：

Romani, Luigina ^{[1
]}

Stincardini, Claudia ^{[1
]}

Giovagnoli, Stefano ^{[2
]}

Paci, Maurizio ^{[3
]}

Villella, Valeria R. ^{[4
]}

Sforna, Luigi ^{[1
]}

Renga, Giorgia ^{[1
]}

Bellet, Marina M. ^{[1
]}

Costantini, Claudio ^{[1
]}

Puccetti, Paolo ^{[1
]}

Kroemer, Guido ^{[5
,6
,7
,8
]}

Maiuri, Luigi ^{[4
,9
]}

Pessia, Mauro ^{[1
]}

Goldstein, Allan ^{[10
]}

Garaci, Enrico ^{[11
]}

机构：

[1] Univ Perugia, Dept Expt Med, Perugia, Italy

[2] Univ Perugia, Dept Pharmaceut Sci, Perugia, Italy

[3] Univ Roma Tor Vergata, Dept Chem Sci & Technol, Rome, Italy

[4] Ist Sci San Raffaele, Div Genet & Cell Biol, European Inst Res Cyst Fibrosis, Milan, Italy

[5] Univ Paris 05, INSERM, U1138, Ctr Rech Cordeliers, Paris, France

[6] Inst Gustave Roussy, Metab & Cell Biol Platforms, Villejuif, France

[7] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[8] Karolinska Univ Hosp, Dept Womens & Childrens Hlth, Karolinska Inst, Stockholm, Sweden

[9] Univ Piemonte Orientale, Dept Hlth Sci, Novara, Italy

[10] George Washington Univ, Sch Med & Hlth Sci, Dept Biochem & Mol Med, Washington, DC 20052 USA

[11] Univ San Raffaele, Rome, Italy

来源：

NATURE MEDICINE | 2018年 / 24卷 / 07期

关键词：

CYSTIC-FIBROSIS; MODEL; INFLAMMATION; AUTOPHAGY;

D O I：

10.1038/s41591-018-0080-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：891 / 893

页数：4

共 12 条

[1]

Chioccioli M., 2017, PREPRINT AT BIORXIV, DOI [10.1101/223024, DOI 10.1101/223024]

[2] The conformation of peptide thymosin α1 in solution and in a membrane-like environment by circular dichroism and NMR spectroscopy.: A possible model for its interaction with the lymphocyte membrane [J].

Grottesi, A ;

Sette, M ;

Palamara, AT ;

Rotilio, G ;

Garaci, E ;

Paci, M .

PEPTIDES, 1998, 19 (10) :1731-1738

[3] Th17/Treg Imbalance in Murine Cystic Fibrosis Is Linked to Indoleamine 2,3-Dioxygenase Deficiency but Corrected by Kynurenines [J].

Iannitti, Rossana G. ;

Carvalho, Agostinho ;

Cunha, Cristina ;

De Luca, Antonella ;

Giovannini, Gloria ;

Casagrande, Andrea ;

Zelante, Teresa ;

Vacca, Carmine ;

Fallarino, Francesca ;

Puccetti, Paolo ;

Massi-Benedetti, Cristina ;

Defilippi, Gloria ;

Russo, Maria ;

Porcaro, Luigi ;

Colombo, Carla ;

Ratclif, Luigi ;

De Benedictis, Fernando. M. ;

Romani, Luigina .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187 (06) :609-620

[4] Epigenome-wide association study of chronic obstructive pulmonary disease and lung function in Koreans [J].

Lee, Mi Kyeong ;

Hong, Yoonki ;

Kim, Sun-Young ;

Kim, Woo Jin ;

London, Stephanie J. .

EPIGENOMICS, 2017, 9 (07) :971-984

[5] Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition [J].

Luciani, Alessandro ;

Villella, Valeria Rachela ;

Esposito, Speranza ;

Brunetti-Pierri, Nicola ;

Medina, Diego ;

Settembre, Carmine ;

Gavina, Manuela ;

Pulze, Laura ;

Giardino, Ida ;

Pettoello-Mantovani, Massimo ;

D'Apolito, Maria ;

Guido, Stefano ;

Masliah, Eliezer ;

Spencer, Brian ;

Quaratino, Sonia ;

Raia, Valeria ;

Ballabio, Andrea ;

Maiuri, Luigi .

NATURE CELL BIOLOGY, 2010, 12 (09) :863-875

[6] New studies about the insertion mechanism of Thymosin α1 in negative regions of model membranes as starting point of the bioactivity [J].

Mandaliti, Walter ;

Nepravishta, Ridvan ;

Vallebona, Paola Sinibaldi ;

Pica, Francesca ;

Garaci, Enrico ;

Paci, Maurizio .

AMINO ACIDS, 2016, 48 (05) :1231-1239

[7] F508del-CFTR is not corrected by thymosin α1 [J].

Matthes, Elizabeth ;

Hanrahan, John W. ;

Cantin, Andre M. .

NATURE MEDICINE, 2018, 24 (07) :890-891

[8] IDO-GCN2 and autophagy in inflammation [J].

McGaha, Tracy L. .

ONCOTARGET, 2015, 6 (26) :21771-21772

[9] Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis [J].

Romani, Luigina ;

Oikonomou, Vasilis ;

Moretti, Silvia ;

Iannitti, Rossana G. ;

D'Adamo, Maria Cristina ;

Villella, Valeria R. ;

Pariano, Marilena ;

Sforna, Luigi ;

Borghi, Monica ;

Bellet, Marina M. ;

Fallarino, Francesca ;

Pallotta, Maria Teresa ;

Servillo, Giuseppe ;

Ferrari, Eleonora ;

Puccetti, Paolo ;

Kroemer, Guido ;

Pessia, Mauro ;

Maiuri, Luigi ;

Goldstein, Allan L. ;

Garaci, Enrico .

NATURE MEDICINE, 2017, 23 (05) :590-+

[10] Scrutiny of electrostatic-driven conformational ordering of polypeptide chains in DMSO: a study with a model oligopeptide [J].

Srivastava, Kinshuk Raj ;

Goyal, Bhupesh ;

Kumar, Anil ;

Durani, Susheel .

RSC ADVANCES, 2017, 7 (45) :27981-27991

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