Are EBV-related and EBV-unrelated Hodgkin lymphomas different with regard to susceptibility to checkpoint blockade?

被引：42

作者：

Carbone, Antonino ^{[1
]}

Gloghini, Annunziata ^{[2
]}

Carlo-Stella, Carmelo ^{[3
,4
]}

机构：

[1] IRCCS, Ist Nazl Tumori, Ctr Riferimento Oncol Aviano, Dept Pathol, Aviano, Italy

[2] Fdn IRCCS, Ist Nazl Tumori, Dept Diagnost Pathol & Lab Med, Milan, Italy

[3] Humanitas Univ, Dept Biomed Sci, Milan, Italy

[4] Humanitas Res Hosp, Humanitas Canc Ctr, Dept Oncol & Hematol, Milan, Italy

来源：

BLOOD | 2018年 / 132卷 / 01期

关键词：

EPSTEIN-BARR-VIRUS; GENOME-WIDE ASSOCIATION; REED-STERNBERG CELLS; MICROENVIRONMENTAL NICHE; BRENTUXIMAB VEDOTIN; ANALYSIS REVEALS; PD-1; BLOCKADE; DISEASE; INFECTION; PEMBROLIZUMAB;

D O I：

10.1182/blood-2018-02-833806

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epstein-Barr virus (EBV)-related and EBV-unrelated classical Hodgkin lymphomas (cHLs) are morphologically and phenotypically indistinguishable. However, the tumor microenvironment of EBV-related cHLs contains higher numbers of macrophages and higher expression levels of PD-L1 than that of EBV-unrelated cHLs. Moreover, viral oncoprotein LMP1 may sustain an immunosuppressive microenvironment by inducing/enhancing production of immunosuppressive cytokines and the expression of PD-1. The presence of enhanced immunosuppressive features in EBV-related cHL should make EBV-related cHL patients more susceptible to checkpoint blockade.

引用

页码：17 / 22

页数：6

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