Various peroxisome proliferator-activated receptor (PPAR)-γ agonists differently induce differentiation of cultured human keratinocytes

被引：13

作者：

Yan, Yan ^{[1
,2
,3
,4
]}

Furumura, Minao ^{[1
,2
]}

Numata, Sanae ^{[1
,2
]}

Teye, Kwesi ^{[1
,2
]}

Karashima, Tadashi ^{[1
,2
]}

Ohyama, Bungo ^{[1
,2
]}

Tanida, Norifumi ^{[5
]}

Hashimoto, Takashi ^{[1
,2
]}

机构：

[1] Kurume Univ, Sch Med, Dept Dermatol, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ, Inst Cutaneous Cell Biol, Kurume, Fukuoka 8300011, Japan

[3] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Dermatol, Beijing 100730, Peoples R China

[4] Peking Union Med Coll, Beijing 100021, Peoples R China

[5] Hisamitsu Pharmaceut Co Inc, Tsukuba Res Labs, Tsukuba, Ibaraki, Japan

来源：

EXPERIMENTAL DERMATOLOGY | 2015年 / 24卷 / 01期

关键词：

filaggrin; keratinocyte; loricrin; peroxisome proliferator-activated receptors; thiazolidinedione; PPAR-GAMMA; EPIDERMAL HOMEOSTASIS; TELMISARTAN; EXPRESSION; LIGANDS; DISEASE; P63;

D O I：

10.1111/exd.12571

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Peroxisome proliferator-activated receptors (PPARs) are potentially useful for the treatment of skin diseases, because they stimulate keratinocyte differentiation, exert anti-inflammatory effects and improve barrier function. We examined five PPAR- agonists, including four thiazolidinediones (ciglitazone, troglitazone, rosiglitazone and pioglitazone) and an angiotensin-II receptor blocker (telmisartan), for their ability to upregulate filaggrin and loricrin expression at both mRNA and protein levels in cultured normal human keratinocytes (NHKs). Troglitazone, rosiglitazone, pioglitazone and telmisartan significantly increased filaggrin expression at both mRNA and protein levels in calcium-induced differentiated NHKs. Rosiglitazone and pioglitazone, but not troglitazone nor telmisartan, also significantly increased loricrin expression at both mRNA and protein levels in differentiated NHKs. These effects were not found in undifferentiated NHKs nor differentiated NHKs treated with ciglitazone. This study revealed differential effects of various PPAR- agonists on epidermal differentiation, and the most potent of those are rosiglitazone and pioglitazone.

引用

页码：62 / 65

页数：4

共 25 条

[1] Structural basis for telmisartan-mediated partial activation of PPAR gamma [J].