The Opposing Forces of the Intestinal Microbiome and the Emerging Pathobiome

被引：53

作者：

Defazio, Jennifer ^{[1
]}

Fleming, Irma D. ^{[1
]}

Shakhsheer, Baddr ^{[1
]}

Zaborina, Olga ^{[1
]}

Alverdy, John C. ^{[1
]}

机构：

[1] Univ Chicago, Pritzker Sch Med, Dept Surg, Ctr Surg Infect Res & Therapeut, Chicago, IL 60637 USA

来源：

SURGICAL CLINICS OF NORTH AMERICA | 2014年 / 94卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Microbiome; Bacteria; Anastomotic leak; Sepsis; Infection; Metabolomics; Proteomics; SURGICAL SITE INFECTIONS; COLORECTAL SURGERY; GASTROINTESTINAL-TRACT; BOWEL PREPARATION; GUT MICROBIOTA; RESISTANCE; OBESITY; METAANALYSIS; THERAPY;

D O I：

10.1016/j.suc.2014.08.002

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This article summarizes emerging concepts on the role of the intestinal microbiome in surgical patients. Revolutionary research over the past decade has shown that human beings live in close and constant contact with boundless communities of microbes. Recent innovations in the study of the human microbiome are reviewed. To demonstrate the applicability of these studies to surgical disease, the authors discuss what is known about the role of microbes in the pathogenesis of perioperative complications. Enhanced awareness of the human microbiome will empower clinicians to adopt novel practices in the prevention and treatment of a variety of surgical conditions.

引用

页码：1151 / +

页数：12

共 49 条

[1] THE CONTRIBUTIONS OF INFECTION CONTROL TO A CENTURY OF SURGICAL PROGRESS [J].