The role of interleukin-17A in the pathogenesis of kidney diseases

被引：98

作者：

Cortvrindt, Charlotte ^{[1
]}

Speeckaert, Reinhart ^{[2
]}

Moerman, Alena ^{[3
]}

Delanghe, Joris R. ^{[3
]}

Speeckaert, Marijn M. ^{[1
]}

机构：

[1] Ghent Univ Hosp, Dept Nephrol, De Pintelaan 185, B-9000 Ghent, Belgium

[2] Ghent Univ Hosp, Dept Dermatol, Ghent, Belgium

[3] Ghent Univ Hosp, Dept Clin Chem, Ghent, Belgium

来源：

PATHOLOGY | 2017年 / 49卷 / 03期

关键词：

Interleukin-17A; inflammation; kidney disease; T-HELPER; 17; GAMMA-DELTA T; TH17; CELLS; GENE POLYMORPHISMS; IL-17; EXPRESSION; LUPUS NEPHRITIS; ACUTE REJECTION; RENAL INJURY; TRANSPLANT RECIPIENTS; EPITHELIAL-CELLS;

D O I：

10.1016/j.pathol.2017.01.003

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a cytokine, produced by multiple cell types, such as CD4(+) ab T cells, gamma delta T cells, natural killer cells, neutrophils, macrophages, dendritic cells, lymphoid tissue inducer cells, mast cells and plasma cells. IL-17A participates in tissue inflammation by inducing the expression of chemokines, proinflammatory cytokines and matrix metalloproteases. Besides its role in host defence against infectious diseases, IL-17A is involved in different autoimmune and inflammatory diseases. In this review, we will highlight the role of IL-17A in the pathogenesis of acute and chronic kidney diseases. Due to its pleiotropic character, IL-17A is involved in the development of atherosclerosis, hypertension, diabetic nephropathy, ischaemia-reperfusion injury, fibrosis, glomerulonephritis, nephrotic syndrome, minimal change disease and acute renal allograft rejection. In addition, inhibition of IL-17A may be a promising therapeutic target to prevent end-stage renal disease.

引用

页码：247 / 258

页数：12

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