Resveratrol and endoplasmic reticulum stress: A review of the potential protective mechanisms of the polyphenol

被引:27
作者
Ahmadi, Ali [1 ]
Hayes, A. Wallace [2 ,3 ]
Karimi, Gholamreza [1 ,4 ]
机构
[1] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran
[2] Univ S Florida, Tampa, FL 33620 USA
[3] Michigan State Univ, E Lansing, MI 48824 USA
[4] Mashhad Univ Med Sci, Inst Pharmaceut Technol, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran
关键词
apoptosis; autophagy; endoplasmic reticulum stress; inflammation; resveratrol; UNFOLDED PROTEIN RESPONSE; IMPROVES INSULIN SENSITIVITY; ACUTE KIDNEY INJURY; ER STRESS; MITOCHONDRIAL DYSFUNCTION; DIABETIC-NEPHROPATHY; MEDIATED APOPTOSIS; HEPATIC STEATOSIS; GENE-EXPRESSION; ADIPOSE-TISSUE;
D O I
10.1002/ptr.7192
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The endoplasmic reticulum (ER) is an organelle that performs a set of essential functions in cellular biology. These include synthesis of lipids, homeostasis of calcium, and controlling the folding of proteins. Inflammation and oxidative stress are two important reasons behind the accumulation of misfolded or unfolded proteins in the ER. In such circumstances, a series of measures are undertaken in the cell which are collectively called unfolded protein response (UPR). The aim of UPR is to reduce the burden of protein aggregates and promote survival. However, extended and unrestricted ER stress (ERS) can induce further inflammation and apoptosis. ERS and the UPR are involved in different diseases such as neurodegenerative and cardiovascular diseases. Resveratrol (RSV), a natural polyphenol, has well-documented evidence supporting its numerous biological properties including antioxidant, antiinflammatory, antiobesity, antidiabetic, and antiischemic activities. The compound is also known for its potential beneficial effects on cognitive function and liver, kidney, and lung health. In this review, the role of ERS in several pathological conditions and the potential protective effects of RSV are discussed. However, the scarcity of clinical data means that more research needs to be conducted to gain a lucid understanding of RSV's effects on endoplasmic reticulum stress (ERS) in humans.
引用
收藏
页码:5564 / 5583
页数:20
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