Design, Synthesis and Biological Evaluation of 2-Phenoxy-N-Phenylacetamides as Novel Anticancer Agents

被引：1

作者：

Shan, Yuanyuan ^{[1
]}

Liu, Fengzhi ^{[2
]}

Ma, Ying ^{[1
]}

Fan, Te ^{[1
]}

Wang, Maoyi ^{[1
]}

Dong, Yalin ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Pharm, Xian 710061, Shaanxi, Peoples R China

[2] Linyi Univ, Sch Chem & Chem Engn, Linyi 276000, Shandong, Peoples R China

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 49卷 / 12期

关键词：

2-phenoxy-N-phenylacetamides; anticancer agents; tyrosine kinase; KDR; EGFR; ANTITUMOR AGENTS; DERIVATIVES;

D O I：

10.1007/s11094-016-1374-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 2-phenoxy-N-phenylacetamides were designed and synthesized with a view to develop novel anticancer agents. All compounds were prepared with varied substitutions in the phenyl ring of aniline and evaluated for their anticancer activity. The majority of them displayed a moderate degree of cytotoxicity against several human cancer cell lines. Six compounds displayed potent cell growth inhibitory activity with IC50 values below 20 mu M. Two compounds (TC-5 and TC-14) exhibited the most pronounced antiproliferative activity equivalent to or higher than that of positive control. The structure - activity relationship of these anticancer agents has been reviewed. The results indicate that incorporation of halogen into the benzene ring is beneficial for anticancer activity.

引用

页码：798 / 803

页数：6

共 8 条

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