Increased Levels of Glycated Hemoglobin A1c and Iron Deficiency Anemia: A Review

被引：62

作者：

Guo, Wenjia ^{[1
]}

Zhou, Qi ^{[2
]}

Jia, Yanan ^{[1
]}

Xu, Jiancheng ^{[1
]}

机构：

[1] First Hosp Jilin Univ, Dept Lab Med, Changchun, Jilin, Peoples R China

[2] First Hosp Jilin Univ, Dept Pediat, Changchun, Jilin, Peoples R China

来源：

MEDICAL SCIENCE MONITOR | 2019年 / 25卷

基金：

美国国家科学基金会;

关键词：

Anemia; Iron-Deficiency; Diabetes Mellitus; Type; 2; Health Care Evaluation Mechanisms; GLYCOSYLATED HEMOGLOBIN; ERYTHROCYTE INDEXES; OXIDATIVE STRESS; HBA1C LEVELS; HBA(1C); ASSOCIATION; A(1C); DIAGNOSIS; CHILDREN; STANDARDIZATION;

D O I：

10.12659/MSM.916719

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Worldwide, the prevalence of diabetes remains high. Studies have shown that iron deficiency anemia (IDA) is associated with increased levels of glycated hemoglobin A1c (HbA1c), but the mechanism remains unclear. Hematological changes, iron metabolism, study methodology, and other factors could affect the results of diagnostic investigations, leading to false results. Red blood cell turnover in the bone marrow and the quality and heterogeneity of erythrocytes may influence the rate of hemoglobin glycation. By changing the structure of hemoglobin and inducing peroxidation, iron deficiency accelerates glycation. This review aims to discuss the possible causes of the association between increased levels of HbA1c and IDA.

引用

页码：8371 / 8378

页数：8

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