Synthetic lethality of KDM1A and mTOR inhibitors: A novel combination therapy for endometrial cancer

被引:0
作者
Pitta-Venkata, Prabhakar [1 ]
Palacios, Bridgitte [1 ]
Chen, Yihong [1 ]
Viswanadhapalli, Suryavathi [1 ]
Pratap, Uday P. [1 ]
Luo, Yiliao [1 ]
Li, Mengxing [1 ]
Altwegg, Kristin [1 ]
Li, Xiaonan [1 ]
Suzuki, Takayoshi [2 ]
Tekmal, Rajeshwar Rao [1 ]
Kost, Edward [1 ]
Sareddy, Gangadhara Reddy [1 ]
机构
[1] UT Hlth San Antonio, San Antonio, TX USA
[2] Kyoto Prefectural Univ Med, Kyoto, Japan
关键词
D O I
10.1158/1538-7445.AM2019-280
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
280
引用
收藏
页数:2
相关论文
共 50 条
[41]   mTOR Signaling Pathway and mTOR Inhibitors in Cancer Therapy [J].
Gomez-Pinillos, Alejandro ;
Ferrari, Anna C. .
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2012, 26 (03) :483-+
[42]   Novel mTOR inhibitors: Promising therapeutic interventions in oral cancer therapy [J].
Ezhilarasan, Devaraj ;
Harini, Karthik Shree .
ORAL ONCOLOGY, 2022, 133
[43]   3,5-Diamino-1,2,4-triazoles as a novel scaffold for potent, reversible LSD1 (KDM1A) inhibitors [J].
Kutz, Craig J. ;
Holshouser, Steven L. ;
Marrow, Ethan A. ;
Woster, Patrick M. .
MEDCHEMCOMM, 2014, 5 (12) :1863-1870
[44]   Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A [J].
Vianello, Paola ;
Botrugno, Oronza A. ;
Cappa, Anna ;
Ciossani, Giuseppe ;
Dessanti, Paola ;
Mai, Antonello ;
Mattevi, Andrea ;
Meroni, Giuseppe ;
Minucci, Saverio ;
Thaler, Florian ;
Tortorici, Marcello ;
Trifiro, Paolo ;
Valente, Sergio ;
Villa, Manuela ;
Varasi, Mario ;
Mercurio, Ciro .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 86 :352-363
[46]   Synthetic lethality of PARP inhibitors and metformin in BRCA1 intact ovarian cancer [J].
Hijaz, M. ;
Chhina, J. ;
Dar, S. ;
Tebbe, C. ;
Al-Wahab, Z. ;
Hanna, R. K. ;
Rattan, R. ;
Munkarah, A. R. .
GYNECOLOGIC ONCOLOGY, 2015, 137 :18-18
[47]   PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer [J].
Chabanon, Roman M. ;
Morel, Daphne ;
Eychenne, Thomas ;
Colmet-Daage, Leo ;
Bajrami, Ilirjana ;
Dorvault, Nicolas ;
Garrido, Marlene ;
Meisenberg, Cornelia ;
Lamb, Andrew ;
Ngo, Carine ;
Hopkins, Suzanna R. ;
Roumeliotis, Theodoros, I ;
Jouny, Samuel ;
Henon, Clemence ;
Kawai-Kawachi, Asuka ;
Astier, Clemence ;
Konde, Asha ;
Del Nery, Elaine ;
Massard, Christophe ;
Pettitt, Stephen J. ;
Margueron, Raphael ;
Choudhary, Jyoti S. ;
Almouzni, Genevieve ;
Soria, Jean-Charles ;
Deutsch, Eric ;
Downs, Jessica A. ;
Lord, Christopher J. ;
Postel-Vinay, Sophie .
CANCER RESEARCH, 2021, 81 (11) :2888-2902
[48]   Significant association between KDM1A promoter hypomethylation and colorectal cancer in Han Chinese [J].
Zhong, Jie ;
Pan, Ranran ;
Ying, Xiuru ;
Wu, Boyi ;
Zhou, Cong ;
Wu, Dongping ;
Ying, Jieer ;
Duan, Shiwei .
PATHOLOGY RESEARCH AND PRACTICE, 2019, 215 (03) :532-538
[49]   Synthetic lethality in cancer treatment: Current status of PARP inhibitors [J].
Calvert, A. H. .
ANNALS OF ONCOLOGY, 2011, 22 :13-13
[50]   PARP Inhibitors in Breast Cancer: Bringing Synthetic Lethality to the Bedside [J].
Turk, Anita A. ;
Wisinski, Kari B. .
CANCER, 2018, 124 (12) :2498-2506