Synthetic lethality of KDM1A and mTOR inhibitors: A novel combination therapy for endometrial cancer

被引:0
|
作者
Pitta-Venkata, Prabhakar [1 ]
Palacios, Bridgitte [1 ]
Chen, Yihong [1 ]
Viswanadhapalli, Suryavathi [1 ]
Pratap, Uday P. [1 ]
Luo, Yiliao [1 ]
Li, Mengxing [1 ]
Altwegg, Kristin [1 ]
Li, Xiaonan [1 ]
Suzuki, Takayoshi [2 ]
Tekmal, Rajeshwar Rao [1 ]
Kost, Edward [1 ]
Sareddy, Gangadhara Reddy [1 ]
机构
[1] UT Hlth San Antonio, San Antonio, TX USA
[2] Kyoto Prefectural Univ Med, Kyoto, Japan
关键词
D O I
10.1158/1538-7445.AM2019-280
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
280
引用
收藏
页数:2
相关论文
共 50 条
  • [1] KDM1A and mTOR inhibition is a novel therapeutic combination for the treatment of endometrial cancer
    Kost, Edward R.
    Prabhakar, Pitta V.
    Sareddy, Gangadhara
    GYNECOLOGIC ONCOLOGY, 2020, 159 (02) : E27 - E27
  • [2] KDM1A inhibition augments the efficacy of rapamycin for the treatment of endometrial cancer
    Venkata, Prabhakar Pitta
    Chen, Yihong
    Alejo, Salvador
    He, Yi
    Palacios, Bridgitte E.
    Loeffel, Ilanna
    Liu, Junhao
    Pratap, Uday P.
    Gray, Gabrielle
    Pillai, Sureshkumar Mulampurath Achuthan
    Zou, Yi
    Lai, Zhao
    Suzuki, Takayoshi
    Viswanadhapalli, Suryavathi
    Palakurthi, Srinath
    Tekmal, Rajeshwar R.
    Vadlamudi, Ratna K.
    Kost, Edward
    Sareddy, Gangadhara R.
    CANCER LETTERS, 2022, 524 : 219 - 231
  • [3] Recent advances of LSD1/KDM1A inhibitors for disease therapy
    Zhang, Chaofeng
    Wang, Zhiyuan
    Shi, Yuting
    Yu, Bin
    Song, Yihui
    BIOORGANIC CHEMISTRY, 2023, 134
  • [4] The Implication of Topoisomerase II Inhibitors in Synthetic Lethality for Cancer Therapy
    Matias-Barrios, Victor M. M.
    Dong, Xuesen
    PHARMACEUTICALS, 2023, 16 (01)
  • [5] Annual review of LSD1/KDM1A inhibitors in 2020
    Fu, Dong-Jun
    Li, Jun
    Yu, Bin
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 214
  • [6] Novel potent inhibitors of the Histone Demethylase KDM1A: Synthesis, pharmacological evaluation and in vivo activity
    Varasi, M.
    Botrugno, O.
    Cappa, A.
    Dal Zuffo, R.
    Dessanti, P.
    Mai, A.
    Mattevi, A.
    Mercurio, C.
    Meroni, G.
    Minucci, S.
    Thaler, F.
    Trifiro, P.
    Valente, S.
    Vianello, P.
    Villa, M.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 : 185 - 185
  • [7] Synthetic lethality in DNA repair network: A novel avenue in targeted cancer therapy and combination therapeutics
    Bhattacharjee, Sonali
    Nandi, Saikat
    IUBMB LIFE, 2017, 69 (12) : 929 - 937
  • [8] The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells
    Tozaki, Yuri
    Aoki, Hiromasa
    Kato, Rina
    Toriuchi, Kohki
    Arame, Saki
    Inoue, Yasumichi
    Hayashi, Hidetoshi
    Kubota, Eiji
    Kataoka, Hiromi
    Aoyama, Mineyoshi
    CANCERS, 2023, 15 (03)
  • [9] Monobenzone, a Novel and Potent KDM1A Inhibitor, Suppresses Migration of Gastric Cancer Cells
    Ma, Peizhi
    Jia, Gang
    Song, Zhiyu
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [10] LSD1/KDM1A inhibitors in clinical trials: advances and prospects
    Yuan Fang
    Guochao Liao
    Bin Yu
    Journal of Hematology & Oncology, 12