Scaling of F-actin network rheology to probe single filament elasticity and dynamics

被引：141

作者：

Gardel, ML ^{[1
]}

Shin, JH

MacKintosh, FC

Mahadevan, L

Matsudaira, PA

Weitz, DA

机构：

[1] Harvard Univ, Dept Phys, Cambridge, MA 02138 USA

[2] Harvard Univ, Div Engn & Appl Sci, Cambridge, MA 02138 USA

[3] MIT, Dept Mech Engn, Cambridge, MA 02142 USA

[4] Whitehead Inst Biomed Res, Dept Biol, Cambridge, MA 02142 USA

[5] MIT, Div Biol Engn, Cambridge, MA 02142 USA

[6] Vrije Univ Amsterdam, Div Phys & Astron, Amsterdam, Netherlands

来源：

PHYSICAL REVIEW LETTERS | 2004年 / 93卷 / 18期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1103/PhysRevLett.93.188102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The linear and nonlinear viscoelastic response of networks of cross-linked and bundled cytoskeletal filaments demonstrates remarkable scaling with both frequency and applied prestress, which helps elucidate the origins of the viscoelasticity. The frequency dependence of the shear modulus reflects the underlying single-filament relaxation dynamics for 0.1-10 rad/sec. Moreover, the nonlinear strain stiffening of such networks exhibits a universal form as a function of prestress; this is quantitatively explained by the full force-extension relation of single semiflexible filaments.

引用

页码：188102 / 1

页数：4

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