Chromium-Catalyzed Asymmetric Dearomatization Addition Reactions of Halomethyl Heteroarenes

被引：34
作者：
Tian, Qingshan [1 ]
Bai, Jing [1 ]
Chen, Bin [1 ]
Zhang, Guozhu [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 08期
关键词：
NOZAKI-HIYAMA ALLYLATION; TRIDENTATE BIS(OXAZOLINYL)CARBAZOLE LIGAND; ENANTIOSELECTIVE SYNTHESIS; NUCLEOPHILIC DEAROMATIZATION; ARYLATIVE DEAROMATIZATION; NAPHTHALENE DERIVATIVES; BIS(OXAZOLINE) LIGANDS; CARBONYL ADDITION; COUPLING REACTION; KISHI REACTION;
D O I：
10.1021/acs.orglett.6b00559
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first asymmetric dearomatization addition reaction of halomethyl arenes including benzofuran and benzothiophene was enabled by chromium catalysis. A variety of aldehydes served as suitable electrophiles under mild reaction conditions. Molecular complexities are quickly increased in a highly diastereo- and enantioselective manner.
引用
收藏
页码：1828 / 1831
页数：4
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