Cardioprotective mechanisms of salvianic acid A sodium in rats with myocardial infarction based on proteome and transcriptome analysis

被引：20

作者：

Jia, Dan ^{[1
]}

Zhang, Cheng-zhong ^{[1
]}

Qiu, Yan ^{[2
]}

Chen, Xiao-fei ^{[1
]}

Jia, Lin ^{[3
]}

Chen, Alex F. ^{[1
]}

Chai, Yi-feng ^{[1
]}

Zhu, Zhen-yu ^{[1
]}

Huang, Jin ^{[4
]}

Zhang, Chuan ^{[1
,5
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China

[2] Shanghai Univ Med & Hlth Sci, Pudong New Area Peoples Hosp, Dept Pharm, Shanghai 201200, Peoples R China

[3] Southern Med Univ, Dept Endodont, Panyu Stomatol Hosp, Guangdong Prov Stomatol Hosp, Guangzhou 511400, Guangdong, Peoples R China

[4] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Dept Pharm, Shanghai 200437, Peoples R China

[5] Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China

来源：

ACTA PHARMACOLOGICA SINICA | 2019年 / 40卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Traditional Chinese medicine; salvianic acid A sodium; myocardial infarction; cardioprotective; proteome; transcriptome; EMBRYONIC STEM-CELLS; ISCHEMIA/REPERFUSION INJURY; CARDIOVASCULAR-DISEASE; DANSHENSU PROTECTS; EXPRESSION; HEART; GENE; DIFFERENTIATION; ASSOCIATION; APOPTOSIS;

D O I：

10.1038/s41401-019-0265-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ischemic heart diseases (IHDs) cause great morbidity and mortality worldwide, necessitating effective treatment. Salvianic acid A sodium (SAAS) is an active compound derived from the well-known herbal medicine Danshen, which has been widely used for clinical treatment of cardiovascular diseases in China. This study aimed to confirm the cardioprotective effects of SAAS in rats with myocardial infarction and to investigate the underlying molecular mechanisms based on proteome and transcriptome profiling of myocardial tissue. The results showed that SAAS effectively protected against myocardial injury and improved cardiac function. The differentially expressed proteins and genes included important structural molecules, receptors, transcription factors, and cofactors. Functional enrichment analysis indicated that SAAS participated in the regulation of actin cytoskeleton, phagosome, focal adhesion, tight junction, apoptosis, MAPK signaling, and Wnt signaling pathways, which are closely related to cardiovascular diseases. SAAS may exert its cardioprotective effect by targeting multiple pathways at both the proteome and transcriptome levels. This study has provided not only new insights into the pathogenesis of myocardial infarction but also a road map of the cardioprotective molecular mechanisms of SAAS, which may provide pharmacological evidence to aid in its clinical application.

引用

页码：1513 / 1522

页数：10

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