The VEGF Gene Polymorphism Impacts Brain Volume and Arterial Blood Volume

被引：11

作者：

Takeuchi, Hikaru ^{[1
]}

Tomita, Hiroaki ^{[2
]}

Taki, Yasuyuki ^{[1
,3
,4
]}

Kikuchi, Yoshie ^{[2
]}

Ono, Chiaki ^{[2
]}

Yu, Zhiqian ^{[2
]}

Sekiguchi, Atsushi ^{[3
,5
,6
]}

Nouchi, Rui ^{[7
]}

Kotozaki, Yuka ^{[8
]}

Nakagawa, Seishu ^{[5
]}

Miyauchi, Carlos Makoto ^{[9
]}

Iizuka, Kunio ^{[5
,10
]}

Yokoyama, Ryoichi ^{[5
,11
]}

Shinada, Takamitsu ^{[5
]}

Yamamoto, Yuki ^{[5
]}

Hanawa, Sugiko ^{[5
]}

Araki, Tsuyoshi ^{[8
]}

Kunitoki, Keiko ^{[12
]}

Sassa, Yuko ^{[1
]}

Kawashima, Ryuta ^{[1
,5
,8
]}

机构：

[1] Tohoku Univ, Div Dev Cognit Neurosci, Inst Dev Aging & Canc, Sendai, Miyagi, Japan

[2] Tohoku Univ, Int Res Inst Disaster Sci, Dept Disaster Psychiat, Sendai, Miyagi, Japan

[3] Tohoku Univ, Tohoku Med Megabank Org, Div Med Neuroimage Anal, Dept Community Med Supports, Sendai, Miyagi, Japan

[4] Tohoku Univ, Dept Nucl Med & Radiol, Inst Dev Aging & Canc, Sendai, Miyagi, Japan

[5] Tohoku Univ, Inst Dev Aging & Canc, Dept Funct Brain Imaging, Sendai, Miyagi, Japan

[6] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Adult Mental Hlth, Tokyo, Japan

[7] Tohoku Univ, Human & Social Response Res Div, Int Res Inst Disaster Sci, Sendai, Miyagi, Japan

[8] Tohoku Univ, Smart Ageing Int Res Ctr, Inst Dev Aging & Canc, Sendai, Miyagi, Japan

[9] Univ Tokyo, Grad Sch Arts & Sci, Dept Gen Syst Studies, Tokyo, Japan

[10] Tohoku Univ, Dept Psychiat, Grad Sch Med, Sendai, Miyagi, Japan

[11] Japan Soc Promot Sci, Tokyo, Japan

[12] Tohoku Univ, Fac Med, Sendai, Miyagi, Japan

来源：

HUMAN BRAIN MAPPING | 2017年 / 38卷 / 07期

关键词：

VEGF; brain; polymorphism; blood volume; brain volume; GROWTH-FACTOR VEGF; VOXEL-BASED MORPHOMETRY; FUNCTIONAL CONNECTIVITY; ALZHEIMERS-DISEASE; FLOW; NEUROGENESIS; PERFUSION; RISK;

D O I：

10.1002/hbm.23606

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Vascular endothelial growth factor (VEGF) plays a critical role in the angiogenesis and proliferation of various types of cells such as neurons, astroglia, and endothelial cells in the brain. A common polymorphism in the VEGF gene (-2578 C/A) is associated with circulating VEGF levels, cancers and Alzheimer's disease. Nonetheless, the effects of this polymorphism on normal human brain volume, arterial blood volume, and blood supply remain unclear. In this study, the effects of this polymorphism on the total gray matter volume (TGMV) and total white matter volume (TWMV) using T1-weighted structural images and the total arterial blood volume (TABV) and mean cerebral blood flow (mCBF) during rest using arterial spin labeling (ASL) in 765 young adult humans were investigated. Voxel-by-voxel whole-brain analyses of these measures were also performed. Multiple regression analyses with age and sex as covariates revealed that the VEGF genotype (number of C alleles) was significantly and positively correlated with TGMV, TWMV, and TABV as well as with regional gray and white matter volumes in widespread areas and regional arterial blood volume in some areas with high arterial blood volume. However, these regional associations were not seen when the corresponding global signal was included as a covariate in the multiple regression analyses, indicating that we failed to obtain evidence of regionspecific associations between these brain measures and the genotype. The results suggest that the VEGF-2578C allele, is associated with changes in the vascular system that lead to increased blood volume and larger brain volume. (C) 2017 Wiley Periodicals, Inc.

引用

页码：3516 / 3526

页数：11

共 48 条

[1] Voxel-based morphometry - The methods [J].