Models and Mechanisms of Local Anesthetic Cardiac Toxicity A Review

被引：71

作者：

Butterworth, John F. ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Anesthesia, Indianapolis, IN 46204 USA

来源：

REGIONAL ANESTHESIA AND PAIN MEDICINE | 2010年 / 35卷 / 02期

关键词：

CENTRAL-NERVOUS-SYSTEM; PIG VENTRICULAR MYOCYTES; CARDIOVASCULAR TOXICITY; SARCOPLASMIC-RETICULUM; SODIUM-CHANNELS; COMPARATIVE CARDIOTOXICITY; INCREMENTAL OVERDOSAGE; STEREOSELECTIVE BLOCK; MOLECULAR-MECHANISMS; BUPIVACAINE TOXICITY;

D O I：

10.1097/AAP.0b013e3181d231b9

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Cardiovascular collapse, even death, may occur after intoxication with bupivacaine or related amide local anesthetic agents. The problem has been studied in myriad laboratories for more than 20 years. Nevertheless, there is consensus neither regarding which animal model best mimics this clinical catastrophe nor as to which ion channel, enzyme, or other local anesthetic binding site represents the point of initiation for the process. This review aimed to define the various credible mechanisms that have been proposed to explain cardiovascular collapse and death after administration of local anesthetics, particularly after bupivacaine and related agents.

引用

页码：167 / 176

页数：10

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