Plants and animals share functionally common bacterial virulence factors

被引：308
|
作者：
Rahme, LG [1 ]
Ausubel, FM
Cao, H
Drenkard, E
Goumnerov, BC
Lau, GW
Mahajan-Miklos, S
Plotnikova, J
Tan, MW
Tsongalis, J
Walendziewicz, CL
Tompkins, RG
机构：
[1] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA
[3] Shriners Burn Inst, Boston, MA 02114 USA
[4] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02114 USA
[5] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
[6] Harvard Univ, Soc Fellows, Cambridge, MA 02138 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 16期
关键词：
D O I：
10.1073/pnas.97.16.8815
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
By exploiting the ability of Pseudomonas aeruginosa to infect a variety of vertebrate and nonvertebrate hosts, we have developed model systems that use plants and nematodes as adjuncts to mammalian models to help elucidate the molecular basis of P. aeruginosa pathogenesis. Our studies reveal a remarkable degree of conservation in the virulence mechanisms used by P. aeruginosa to infect hosts of divergent evolutionary origins.
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页码：8815 / 8821
页数：7
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