Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602

被引：136

作者：

Rascher, A

Hu, ZH

Viswanathan, N

Schirmer, A

Reid, R

Nierman, WC

Lewis, M

Hutchinson, CR

机构：

[1] Kosan Biosci, Hayward, CA 94545 USA

[2] Inst Genome Res, Rockville, MD 20850 USA

来源：

FEMS MICROBIOLOGY LETTERS | 2003年 / 218卷 / 02期

关键词：

ansamycin; antitumor; biosynthesis; cancer chemotherapy; Hsp90; polyketide synthase;

D O I：

10.1016/S0378-1097(02)01148-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We illustrate the use of a PCR-based method by which the genomic DNA of a microorganism can be rapidly queried for the presence of type I modular polyketide synthase genes to clone and characterize, by sequence analysis and gene disruption, a major portion of the geldanamycin production gene cluster from Streptomyces hygroscopicus var. geldanus NRRL 3602. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：223 / 230

页数：8

共 50 条

[41] Characterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570
Houyuan Zhao
Liang Wang
Dan Wan
Jianzhao Qi
Rong Gong
Zixin Deng
Wenqing Chen
Microbial Cell Factories, 15
[42] Characterization of the aurantimycin biosynthetic gene cluster and enhancing its production by manipulating two pathway-specific activators in Streptomyces aurantiacus JA 4570
Zhao, Houyuan
Wang, Liang
Wan, Dan
Qi, Jianzhao
Gong, Rong
Deng, Zixin
Chen, Wenqing
MICROBIAL CELL FACTORIES, 2016, 15 : 1
[43] Analysis of the Tunicamycin Biosynthetic Gene Cluster of Streptomyces chartreusis Reveals New Insights into Tunicamycin Production and Immunity
Widdick, David
Royer, Sylvain F.
Wang, Hua
Vior, Natalia M.
Gomez-Escribano, Juan Pablo
Davis, Benjamin G.
Bibb, Mervyn J.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (08)
[44] Characterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802
Tu, Jiajia
Li, Siting
Chen, Jiang
Song, Yongxiang
Fu, Shaobin
Ju, Jianhua
Li, Qinglian
MICROBIAL CELL FACTORIES, 2018, 17
[45] Characterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802
Jiajia Tu
Siting Li
Jiang Chen
Yongxiang Song
Shaobin Fu
Jianhua Ju
Qinglian Li
Microbial Cell Factories, 17
[46] The blasticidin S biosynthesis gene cluster from Streptomyces griseochromogenes:: Sequence analysis, organization, and initial characterization
Cone, MC
Yin, XH
Grochowski, LL
Parker, MR
Zabriskie, TM
CHEMBIOCHEM, 2003, 4 (09) : 821 - 828
[47] Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256
Fumitaka Kudo
Takanori Yonezawa
Akiko Komatsubara
Kazutoshi Mizoue
Tadashi Eguchi
The Journal of Antibiotics, 2011, 64 : 123 - 132
[48] Identification and Characterization of the StreptazoneE Biosynthetic Gene Cluster in Streptomyces sp MSC090213JE08
Ohno, Shoto
Katsuyama, Yohei
Tajima, Yuka
Izumikawa, Miho
Takagi, Motoki
Fujie, Manabu
Satoh, Noriyuki
Shin-ya, Kazuo
Ohnishi, Yasuo
CHEMBIOCHEM, 2015, 16 (16) : 2385 - 2391
[49] Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster in Streptomyces sp MSC090213JE08
Du, Danyao
Katsuyama, Yohei
Onaka, Hiroyasu
Fujie, Manabu
Satoh, Noriyuki
Shin-ya, Kazuo
Ohnishi, Yasuo
CHEMBIOCHEM, 2016, 17 (15) : 1464 - 1471
[50] Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus':: evidence for the derailment of an aromatic polyketide synthase
Piel, J
Hertweck, C
Shipley, PR
Hunt, DM
Newman, MS
Moore, BS
CHEMISTRY & BIOLOGY, 2000, 7 (12): : 943 - 955

← 1 2 3 4 5 →