Dietary fibre linked to decreased inflammation in overweight minority youth

Objective: The objective of this study was to examine the relationship between diet and inflammation, and adiposity in minority youth. Design and Methods: The study was designed as a cross-sectional analysis of 142 overweight (>= 85th body mass index percentile) Hispanic and AfricanAmerican adolescents (14-18 years) with the following measures: anthropometrics, adiposity via magnetic resonance imaging, dietary intake via 24-h dietary recalls, and inflammation markers from fasting blood draws utilizing a multiplex panel. Partial correlations were estimated and analysis of covariance (ANCOVA) models fit to examine the relationship among dietary variables, inflammation markers and adiposity measures with the following a priori covariates: Tanner stage, ethnicity, sex, total energy intake, total body fat and total lean mass. Results: Inference based on ANCOVA models showed that the highest tertile of fibre intake (mean intake of 21.3 +/- 6.1 g d(-1)) vs. the lowest tertile of fibre intake (mean intake of 7.4 +/- 1.8 g d(-1)) was associated with 36% lower plasminogen activator inhibitor-1 (P = 0.02) and 43% lower resistin (P = 0.02), independent of covariates. Similar results were seen for insoluble fibre. No other dietary variables included in this study were associated with inflammation markers. Conclusions: These results suggest that increases in dietary fibre could play an important role in lowering inflammation and therefore metabolic disease risk in high-risk minority youth.