Chronic DLL4 blockade induces vascular neoplasms

被引:231
作者
Yan, Minhong [1 ]
Callahan, Christopher A. [2 ]
Beyer, Joseph C. [2 ]
Allamneni, Krishna P. [3 ]
Zhang, Gu [1 ]
Ridgway, John Brady [1 ]
Niessen, Kyle [1 ]
Plowman, Greg D. [1 ]
机构
[1] Genentech Inc, Dept Tumor Biol & Angiogenesis, San Francisco, CA 94080 USA
[2] Genentech Inc, Dept Pathol, San Francisco, CA 94080 USA
[3] Genentech Inc, Dept Toxicol, San Francisco, CA 94080 USA
关键词
INHIBITS TUMOR-GROWTH; ENDOTHELIAL-CELLS; ANGIOGENESIS; MIGRATION;
D O I
10.1038/nature08751
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Arising from: J. Ridgway et al.Nature444, 1083–1087 (2006)10.1038/nature05313
引用
收藏
页码:E6 / E7
页数:2
相关论文
共 9 条
  • [1] [Anonymous], PHASE 1 DOSE ESCALAT
  • [2] [Anonymous], A Multiple Ascending Dose Phase I Study of SB 9200 in Treatment Naive Adults With Chronic Hepatitis C Infection
  • [3] Promoting angiogenesis to a fault
    Hicklin, Daniel J.
    [J]. NATURE BIOTECHNOLOGY, 2007, 25 (03) : 300 - 302
  • [4] Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells
    Hsieh, S. H.
    Ying, N. W.
    Wu, M. H.
    Chiang, W. F.
    Hsu, C. L.
    Wong, T. Y.
    Jin, Y. T.
    Hong, T. M.
    Chen, Y. L.
    [J]. ONCOGENE, 2008, 27 (26) : 3746 - 3753
  • [5] Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications
    Li, Ji-Liang
    Harris, Adrian L.
    [J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 : 3094 - 3110
  • [6] Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    Noguera-Troise, Irene
    Daly, Christopher
    Papadopoulos, Nicholas J.
    Coetzee, Sandra
    Boland, Pat
    Gale, Nicholas W.
    Lin, Hsin Chieh
    Yancopoulos, George D.
    Thurston, Gavin
    [J]. NATURE, 2006, 444 (7122) : 1032 - 1037
  • [7] Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    Ridgway, John
    Zhang, Gu
    Wu, Yan
    Stawicki, Scott
    Liang, Wei-Ching
    Chanthery, Yvan
    Kowalski, Joe
    Watts, Ryan J.
    Callahan, Christopher
    Kasman, Ian
    Singh, Mallika
    Chien, May
    Tan, Christine
    Hongo, Jo-Anne S.
    de Sauvage, Fred
    Plowman, Greg
    Yan, Minhong
    [J]. NATURE, 2006, 444 (7122) : 1083 - 1087
  • [8] EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution
    Schmidt, Maike
    Paes, Kim
    De Maziere, Ann
    Smyczek, Tanya
    Yang, Stacey
    Gray, Alane
    French, Dorothy
    Kasman, Ian
    Klumperman, Judith
    Rice, Dennis S.
    Ye, Weilan
    [J]. DEVELOPMENT, 2007, 134 (16): : 2913 - 2923
  • [9] SETONROGERS S, 2007, NATURE REV CANC, V7, P72