Key signalling nodes in mammary gland development and cancer Myc

被引：61

作者：

Hynes, Nancy E. ^{[1
]}

Stoelzle, Tina ^{[1
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland

来源：

BREAST CANCER RESEARCH | 2009年 / 11卷 / 05期

关键词：

HUMAN BREAST-CANCER; C-MYC; ESTROGEN-RECEPTOR; EPITHELIAL-CELLS; WNT PATHWAY; GENE-EXPRESSION; TRANSGENIC MICE; PROLIFERATION; NOTCH; MECHANISM;

D O I：

10.1186/bcr2406

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myc has been intensely studied since its discovery more than 25 years ago. Insight has been gained into Myc's function in normal physiology, where its role appears to be organ specific, and in cancer where many mechanisms contribute to aberrant Myc expression. Numerous signals and pathways converge on Myc, which in turn acts on a continuously growing number of identified targets, via transcriptional and nontranscriptional mechanisms. This review will concentrate on Myc as a signaling mediator in the mammary gland, discussing its regulation and function during normal development, as well as its activation and roles in breast cancer.

引用

页数：9

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