Key signalling nodes in mammary gland development and cancer Myc

被引：61
作者：
Hynes, Nancy E. [1 ]
Stoelzle, Tina [1 ]
机构：
[1] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
来源：
BREAST CANCER RESEARCH | 2009年 / 11卷 / 05期
关键词：
HUMAN BREAST-CANCER; C-MYC; ESTROGEN-RECEPTOR; EPITHELIAL-CELLS; WNT PATHWAY; GENE-EXPRESSION; TRANSGENIC MICE; PROLIFERATION; NOTCH; MECHANISM;
D O I：
10.1186/bcr2406
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Myc has been intensely studied since its discovery more than 25 years ago. Insight has been gained into Myc's function in normal physiology, where its role appears to be organ specific, and in cancer where many mechanisms contribute to aberrant Myc expression. Numerous signals and pathways converge on Myc, which in turn acts on a continuously growing number of identified targets, via transcriptional and nontranscriptional mechanisms. This review will concentrate on Myc as a signaling mediator in the mammary gland, discussing its regulation and function during normal development, as well as its activation and roles in breast cancer.
引用
收藏
页数：9
相关论文
共 50 条
  • [21] The Role of C/EBPβ in Mammary Gland Development and Breast Cancer
    Sandra L. Grimm
    Jeffrey M. Rosen
    Journal of Mammary Gland Biology and Neoplasia, 2003, 8 : 191 - 204
  • [22] Mammary Gland Growth Factors: Roles in Normal Development and in Cancer
    Hynes, Nancy E.
    Watson, Christine J.
    COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (08): : a003186
  • [23] Epigenomics of mammary gland development
    Holliday, Holly
    Baker, Laura A.
    Junankar, Simon R.
    Clark, Susan J.
    Swarbrick, Alexander
    BREAST CANCER RESEARCH, 2018, 20
  • [24] STEM CELLS AND THE DIFFERENTIATION HIERARCHY IN MAMMARY GLAND DEVELOPMENT
    Fu, Nai Yang
    Nolan, Emma
    Lindeman, Geoffrey J.
    Visvader, Jane E.
    PHYSIOLOGICAL REVIEWS, 2020, 100 (02) : 489 - 523
  • [25] Molecular Mechanisms Guiding Embryonic Mammary Gland Development
    Cowin, Pamela
    Wysolmerski, John
    COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (06): : a003251
  • [26] Psychosocial Stress Exposure Disrupts Mammary Gland Development
    Johnson, Marianna B.
    Hoffmann, Joscelyn N.
    You, Hannah M.
    Lastra, Ricardo R.
    Fernandez, Sully
    Strober, Jordan W.
    Allaw, Ahmad B.
    Brady, Matthew J.
    Conzen, Suzanne D.
    McClintock, Martha K.
    JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2018, 23 (1-2) : 59 - 73
  • [27] Cell-Matrix Interactions in Mammary Gland Development and Breast Cancer
    Muschler, John
    Streuli, Charles H.
    COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (10): : a003202
  • [28] Role of dietary fatty acids in mammary gland development and breast cancer
    MacLennan, Mira
    Ma, David W. L.
    BREAST CANCER RESEARCH, 2010, 12 (05)
  • [29] Microenvironmental control of cell fate decisions in mammary gland development and cancer
    Rauner, Gat
    Kuperwasser, Charlotte
    DEVELOPMENTAL CELL, 2021, 56 (13) : 1875 - 1883
  • [30] Mammary gland stem cells and their application in breast cancer
    Yang, Xing
    Wang, Hui
    Jiao, Baowei
    ONCOTARGET, 2017, 8 (06) : 10675 - 10691
12345