A Biological Basis for Pharmacokinetics: The Remote Sensing and Signaling Theory

被引：10
作者：
Nigam, Sanjay K. [1 ,2 ]
Granados, Jeffry C. [3 ]
机构：
[1] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2022年 / 112卷 / 03期
基金：
美国国家卫生研究院;
关键词：
TRANSPORTERS; ACCUMULATION;
D O I：
10.1002/cpt.2634
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
What do drug transporters and drug metabolizing enzymes (DMEs)-as well as the various regulatory proteins involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs-really do?(1) To those coming from a non-pharmaceutical background, this seems a very reasonable, if not urgent, question. What do they really do? What is their true biological function?
引用
收藏
页码：456 / 460
页数：5
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