Long-term sensitivity of uterus and hypothalamus/pituitary axis to 17β-estradiol is higher than that of bone in rats

被引：11

作者：

Erben, RG ^{[1
]}

Brunner, KS ^{[1
]}

Breig, B ^{[1
]}

机构：

[1] Univ Munich, Inst Physiol Physiol Chem & Anim Nutr, Munich, Germany

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 11期

关键词：

estrogen; uterus; follicle-stimulating hormone; bone; histomorphometry; osteoporosis; rats;

D O I：

10.1359/JBMR.040815

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined the long-term sensitivity of uterus and bone to low-dose 17beta-estradiol in a 4-month experiment in OVX rats and found that a dose of estradiol that fully protected against uterine atrophy did not protect against bone loss. Our results suggest higher estrogen sensitivity of the uterus compared with bone.

引用

页码：1827 / 1832

页数：6

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