Four New Picrotoxane-Type Sesquiterpenes From Dendrobium nobile Lindl

被引：27

作者：

Wang, Pei ^{[1
]}

Chen, Xin ^{[1
,2
]}

Wang, Hao ^{[1
]}

Huang, Shengzhuo ^{[1
]}

Cai, Caihong ^{[1
]}

Yuan, Jingzhe ^{[1
]}

Zhu, Guoliang ^{[3
]}

Xu, Xinglian ^{[2
]}

Mei, Wenli ^{[1
]}

Dai, Haofu ^{[1
]}

机构：

[1] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou, Hainan, Peoples R China

[2] Nanjing Agr Univ, Nanjing, Jiangsu, Peoples R China

[3] East China Univ Sci & Technol, Shanghai, Peoples R China

来源：

FRONTIERS IN CHEMISTRY | 2019年 / 7卷

关键词：

Dendrobium nobile Lindl; picrotoxane; sesquiterpenes; alpha-glycosidase inhibitor; cytotoxicity; BIBENZYL DERIVATIVES; INHIBITORS; GROWTH; STEMS;

D O I：

10.3389/fchem.2019.00812

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four picrotoxane-type sesquiterpenes, dendroterpene A-D (1-4), together with four known compounds (5-8), were isolated from the stems of Dendrobium nobile Lindl. Their structures were elucidated by spectroscopic analysis, X-ray diffraction analysis, analysis of the ECD data according to the Klyne's lactone sector rule, and quantum ECD calculation. Compounds 1 and 2 are two new picrotoxane-type sesquiterpenes with a new carbon skeleton containing a formamide group, which may be derived from the previously reported dendrobiumane B skeleton by the C(9)-C(11) carbon bond cleavage. Compounds 3, 5, 6, and 8 exhibited inhibitory activity against alpha-glycosidase. Compounds 5 and 6 were cytotoxic against SGC-7901, K562, A549, BEL-7402, and Hela cell lines.

引用

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