Heterogeneity of virulence-related properties in Listeria monocytogenes strains isolated from patients with haematological malignancies

被引：7
作者：
Longhi, C
Penta, M
Conte, MP
Girmenia, C
Seganti, L
机构：
[1] Univ Roma La Sapienza, Dept Publ Hlth Sci, I-00185 Rome, Italy
[2] Univ Roma La Sapienza, Dept Cellular Biotechnol & Haematol, I-00185 Rome, Italy
来源：
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2003年 / 16卷 / 02期
关键词：
Listeria monocytogenes; virulence; haematological malignancies; immunocompromised host;
D O I：
10.1177/039463200301600205
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Listeria monocytogenes is an intracellular foodborne pathogen of humans and animals for which there are indications of virulence differences among strains. Various virulence properties related to different phases of infection process were investigated in L. monocytogenes strains isolated from patients affected by haematological malignancies. In these isolates, besides to the clinical history, we analysed the haemolysin production, the survival to acidic pH, the ability to enter and proliferate in human intestinal-like and human macrophagic-like cells, as well as the allelic polymorphism of the actA gene involved in intracellular movement. A general heterogeneity in the virulence properties was detected which did not appear correlated with the clinical outcome of listeriosis but more probably was influenced by the status of the immune defence of the host.
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页码：119 / 127
页数：9
相关论文
共 41 条
[1]   LISTERIOSIS IN PATIENTS WITH CHRONIC LYMPHOCYTIC-LEUKEMIA WHO WERE TREATED WITH FLUDARABINE AND PREDNISONE [J].
ANAISSIE, E ;
KONTOYIANNIS, DP ;
KANTARJIAN, H ;
ELTING, L ;
ROBERTSON, LE ;
KEATING, M .
ANNALS OF INTERNAL MEDICINE, 1992, 117 (06) :466-469
[2]  
BROSCH R, 1993, J FOOD PROTECT, V56, P296, DOI 10.4315/0362-028X-56.4.297
[3]   CLINICAL AND LABORATORY ASPECTS OF LISTERIA MONOCYTOGENES INFECTIONS - WITH A REPORT OF 10 CASES [J].
BUCHNER, LH ;
SCHNEIERSON, SS .
AMERICAN JOURNAL OF MEDICINE, 1968, 45 (06) :904-+
[4]   LISTERIA-MONOCYTOGENES INFECTION OF CACO-2 CELLS - ROLE OF GROWTH TEMPERATURE [J].
CONTE, MP ;
LONGHI, C ;
PETRONE, G ;
POLIDORO, M ;
VALENTI, P ;
SEGANTI, L .
RESEARCH IN MICROBIOLOGY, 1994, 145 (09) :677-682
[5]   Iron availability affects entry of Listeria monocytogenes into the enterocytelike cell line Caco-2 [J].
Conte, MP ;
Longhi, C ;
Polidoro, M ;
Petrone, G ;
Buonfiglio, V ;
DiSanto, S ;
Papi, E ;
Seganti, L ;
Visca, P ;
Valenti, P .
INFECTION AND IMMUNITY, 1996, 64 (09) :3925-3929
[6]   Modulation of actA gene expression in Listeria monocytogenes by iron [J].
Conte, MP ;
Longhi, C ;
Petrone, G ;
Polidoro, M ;
Valenti, P ;
Seganti, L .
JOURNAL OF MEDICAL MICROBIOLOGY, 2000, 49 (08) :681-683
[7]   Effect of acid adaptation on the fate of Listeria monocytogenes in THP-1 human macrophages activated by gamma interferon [J].
Conte, MP ;
Petrone, G ;
Di Biase, AM ;
Longhi, C ;
Penta, M ;
Tinari, A ;
Superti, F ;
Fabozzi, G ;
Visca, P ;
Seganti, L .
INFECTION AND IMMUNITY, 2002, 70 (08) :4369-4378
[8]   Acid tolerance in Listeria monocytogenes influences invasiveness of enterocyte-like cells and macrophage-like cells [J].
Conte, MP ;
Petrone, G ;
Di Biase, AM ;
Ammendolia, MG ;
Superti, F ;
Seganti, L .
MICROBIAL PATHOGENESIS, 2000, 29 (03) :137-144
[9]   Acid tolerance in Listeria monocytogenes: The adaptive acid tolerance response (ATR) and growth-phase-dependent acid resistance [J].
Davis, MJ ;
Coote, PJ ;
OByrne, CP .
MICROBIOLOGY-UK, 1996, 142 :2975-2982
[10]   FATE OF LISTERIA-MONOCYTOGENES IN MURINE MACROPHAGES - EVIDENCE FOR SIMULTANEOUS KILLING AND SURVIVAL OF INTRACELLULAR BACTERIA [J].
DECHASTELLIER, C ;
BERCHE, P .
INFECTION AND IMMUNITY, 1994, 62 (02) :543-553
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