Efficacy of low-dose levothyroxine combined with thiamazole for treatment of patients with hyperthyroidism

Objective: The current study aimed to explore the efficacy of low-dose levothyroxine combined with thiamazole (LL&T) for treatment of patients with hyperthyroidism, examining its effects on thyroid hormone, bone metabolism, and recurrence rates. Methods: A total of 86 patients with hyperthyroidism (PH), admitted from January 2016 to January 2017, were enrolled in this study. According to the random number table method, they were divided into the control group (CG) and study group (SG), with 43 cases in each group. The control group was given thiamazole, while the study group was given LL&T. Efficacy, thyroid hormone, bone metabolism, and 2-year recurrence rates were compared between the two groups. Results: The total effective rate of SG (88.37%) was higher than that of CG (69.77%) (P<0.05). After treatment, hormonal indexes of both groups were improved. Of these, SGTT3, TT4, FT3, and FT4 were lower, while TSH was higher, compared to those in CG (P<0.05). Bone metabolism outcomes were improved after treatment. SGCT, BGP, BALP, and PINP levels were lower in SG (P<0.05). There were no differences in incidence of adverse reactions between the two groups (P>0.05). Conclusion: LL&T has remarkable efficacy in the treatment of hyperthyroidism. It can improve levels of thyroid hormone and bone metabolism outcomes of PH. Moreover, it can reduce recurrence rates. Thus, it is worthy of promotion.