Copper-Based Metal Organic Framework Nanoparticles with Peroxidase-Like Activity for Sensitive Colorimetric Detection of Staphylococcus aureus

被引:263
作者
Wang, Shuqin [1 ]
Deng, Wenfang [1 ]
Yang, Lu [1 ]
Tan, Yueming [1 ]
Xie, Qngji [1 ]
Yao, Shouzhuo [1 ]
机构
[1] Hunan Normal Univ, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ China, Coll Chem & Chem Engn, Changsha 410081, Hunan, Peoples R China
基金
中国国家自然科学基金;
关键词
metal-organic framework; peroxidase-like activity; chromogenic reaction; pathogenic bacteria; Staphylococcus aureus; ZEOLITIC IMIDAZOLATE FRAMEWORK; CATALYTIC-ACTIVITY; PLATFORM; SEPARATION; STRATEGY; BACTERIA;
D O I
10.1021/acsami.7b07307
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Cu-MOF nanoparticles with an average diameter of 550 nm were synthesized from 2-aminoterephthalic acid and Cu(NO3)(2) by a mixed solvothermal method. The Cu-MOF nanoparticles can show peroxidase-like activity that can catalyze 3,3',5,5'-tetramethylbenzidine to produce a yellow chromogenic reaction in the presence of H2O2. The presence of abundant amine groups on the surfaces of Cu-MOF nanoparticles enables facile modification of Staphylococcus aureus (S. aureus) aptamer on Cu-MOF nanoparticles. By combining Cu-MOF-catalyzed chromogenic reaction with aptamer recognition and magnetic separation, a simple, sensitive, and selective colorimetric method for the detection of S. aureus was developed.
引用
收藏
页码:24440 / 24445
页数:6
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