Potential Roles of Exosomal MicroRNAs as Diagnostic Biomarkers and Therapeutic Application in Alzheimer's Disease

被引：107
作者：
Chen, Jian-jiao [1 ,2 ]
Zhao, Bin [3 ]
Zhao, Jie [1 ,3 ]
Li, Shao [1 ]
机构：
[1] Dalian Med Univ, Liaoning Prov Key Lab Cerebral Dis, Dept Physiol, Dalian 116044, Liaoning, Peoples R China
[2] Subei Peoples Hosp Jiangsu Prov, Dept Gen Surg, Yangzhou 225000, Jiangsu, Peoples R China
[3] Dalian Med Univ, Technol Ctr Target Based Nat Prod Prevent & Treat, Dalian, Liaoning, Peoples R China
来源：
NEURAL PLASTICITY | 2017年 / 2017卷
基金：
中国国家自然科学基金;
关键词：
MESENCHYMAL STROMAL CELLS; AMYLOID PRECURSOR PROTEIN; CEREBROSPINAL-FLUID; NEUROVASCULAR PLASTICITY; FUNCTIONAL RECOVERY; EMERGING ROLES; UP-REGULATION; MOUSE MODEL; STEM-CELLS; BRAIN;
D O I：
10.1155/2017/7027380
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Exosomes are bilipid layer-enclosed vesicles derived from endosomes and are released from neural cells. They contain a diversity of proteins, mRNAs, and microRNAs (miRNAs) that are delivered to neighboring cells and/or are transported to distant sites. miRNAs released from exosomes appear to be associated with multiple neurodegenerative conditions linking to Alzheimer's disease (AD) which is marked by hyperphosphorylated tau proteins and accumulation of A beta plaques. Exciting findings reveal that miRNAs released from exosomes modulate the expression and function of amyloid precursor proteins (APP) and tau proteins. These open up the possibility that dysfunctional exosomal miRNAs may influence AD progression. In addition, it has been confirmed that the interaction between miRNAs released by exosomes and Toll-like receptors (TLR) initiates inflammation. In exosome support-deprived neurons, exosomal miRNAs may regulate neuroplasticity to relieve neurological damage. In this review, we summarize the literature on the function of exosomal miRNAs in AD pathology, the potential of these miRNAs as diagnostic biomarkers in AD, and the use of exosomes in the delivery of miRNAs which may lead to major advances in the field of macromolecular drug delivery.
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页数：12
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