The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses

被引：119

作者：

Yost, Christian C. ^{[1
,2
]}

Weyrich, Andrew S. ^{[1
,3
]}

Zimmerman, Guy A. ^{[1
,3
]}

机构：

[1] Univ Utah, Eccles Inst Human Genet, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Pediat, Salt Lake City, UT 84112 USA

[3] Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA

来源：

BIOCHIMIE | 2010年 / 92卷 / 06期

关键词：

Platelet-activating factor; Sepsis; Anaphylaxis; Inflammation; Lipid mediators; FACTOR RECEPTOR ANTAGONIST; RESPIRATORY-DISTRESS-SYNDROME; MULTIPLE ORGAN FAILURE; ACUTE LUNG INJURY; PHASE-II TRIAL; NF-KAPPA-B; FACTOR-ACETYLHYDROLASE; SEVERE SEPSIS; DOUBLE-BLIND; CLINICAL-TRIAL;

D O I：

10.1016/j.biochi.2010.02.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The platelet-activating factor (PAF) signaling cascade evolved as a component of the repertoire of innate host defenses, but is also an effector pathway in inflammatory and thrombotic diseases. This review focuses on the PAF signaling cascade in systemic inflammatory responses and, specifically, explores its activities in experimental and clinical sepsis and anaphylaxis in the context of the basic biochemistry and biology of signaling via this lipid mediator system. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：692 / 697

页数：6

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