Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use

被引：82

作者：

Sekar, Sanathana Konugolu Venkata ^{[1
]}

Mora, Alberto Dalla ^{[1
]}

Bargigia, Ilaria ^{[2
]}

Martinenghi, Edoardo ^{[1
]}

Lindner, Claus ^{[3
]}

Farzam, Parisa ^{[3
]}

Pagliazzi, Marco ^{[3
]}

Durduran, Turgut ^{[3
,4
]}

Taroni, Paola ^{[1
]}

Pifferi, Antonio ^{[1
]}

Farina, Andrea ^{[5
]}

机构：

[1] Politecn Milan, Dipartimento Fis, I-20133 Milan, Italy

[2] Ist Italiano Tecnol, I-20133 Milan, Italy

[3] Barcelona Inst Sci & Technol, ICFO Inst Ciencies Foton, Barcelona 08860, Spain

[4] Inst Catalana Recerca & Estudis Avancats, Barcelona 08015, Spain

[5] CNR, Ist Foton & Nanotecnol, I-20133 Milan, Italy

来源：

IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS | 2016年 / 22卷 / 03期

关键词：

Broadband; time-resolved; turbid media; in-vivo; silicon photomultiplier (SiPM); diffuse optics; absorption; scattering; NEAR-INFRARED SPECTROSCOPY; IN-VIVO ABSORPTION; FREQUENCY-DOMAIN; PHOTON MIGRATION; TURBID MEDIA; REFLECTANCE; TISSUE; BREAST; TRANSMITTANCE; PENETRATION;

D O I：

10.1109/JSTQE.2015.2506613

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We report on the design, development, and performance assessment of a portable time-resolved system measuring absorption and scattering spectra of highly diffusive media over the 600-1350 nm range. In view of clinical use, two strategies were implemented; the first one equips the system with high responsivity in key tissue absorbing regions, whereas the second one makes the system immune to time drift. The MEDPHOT protocol was used for the performance assessment of the instrument. Finally, the system was enrolled into its first in vivo trial phase, measuring the broadband absorption and scattering spectra of human manubrium, abdomen fat tissues, and forehead for the in vivo quantification of key tissue constituents.

引用

页码：406 / 414

页数：9

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