The 'reversibility' of chronic atrophic gastritis after the eradication of Helicobacter pylori

被引:36
作者
Yang, Hang [1 ]
Zhou, Xinyue [1 ]
Hu, Bing [1 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Gastroenterol, 37 Guo Xue Alley, Chengdu 610041, Sichuan, Peoples R China
关键词
Chronic atrophic gastritis; Helicobacter pylori; pathogenesis; management; reversibility; INTESTINAL METAPLASIA; STEM-CELLS; CAGA PROTEIN; FOLLOW-UP; TYROSINE PHOSPHATASE; HISTOLOGICAL-CHANGES; MUCOSAL ATROPHY; CANCER; INFECTION; PROGRESSION;
D O I
10.1080/00325481.2022.2063604
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Gram-negative bacterium Helicobacter pylori (H. pylori) infection is lifelong and usually acquired in childhood, which is etiologically linked to gastric cancer (GC). H. pylori gastritis is defined as an infectious disease with varying severity in virtually all infected subjects. Chronic atrophic gastritis (CAG) is the precancerous condition with the decrease or the loss of gastric glands, which can further be replaced by metaplasia or fibrosis. Patients with advanced stages of CAG are at higher risk of GC and should be followed up with a high-quality endoscopy every 3 years. H. pylori infection is the most common cause and its eradication is recommended, which may contribute to the regression of CAG. However, it is controversial whether CAG is reversible after eradication therapy. In the review, we discuss recent studies which provide important insights into whether CAG is 'reversibility' and when it may progress into GC after eradicating H. pylori.
引用
收藏
页码:474 / 479
页数:6
相关论文
共 103 条
  • [1] Modulation of Stem Cell Progeny by Probiotics during Regeneration of Gastric Mucosal Erosions
    Al-Yassir, Farah
    Khoder, Ghalia
    Sugathan, Subi
    Saseedharan, Prashanth
    Al Menhali, Asma
    Karam, Sherif M.
    [J]. BIOLOGY-BASEL, 2021, 10 (07):
  • [2] Pathobiology of Helicobacter pylori-Induced Gastric Cancer
    Amieva, Manuel
    Peek, Richard M., Jr.
    [J]. GASTROENTEROLOGY, 2016, 150 (01) : 64 - 78
  • [3] Annibale B, 2000, ALIMENT PHARM THERAP, V14, P625
  • [4] The long-term effects of cure of Helicobacter pylori infection on patients with atrophic body gastritis
    Annibale, B
    Di Giulio, E
    Caruana, P
    Lahner, E
    Capurso, G
    Bordi, C
    Delle Fave, G
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2002, 16 (10) : 1723 - 1731
  • [5] Helicobacter pylori eradication in the healing of atrophic gastritis:: A one-year prospective study
    Arkkila, PET
    Seppälä, K
    Färkkilä, MA
    Veijola, L
    Sipponen, P
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2006, 41 (07) : 782 - 790
  • [6] Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035
    Arnold, Melina
    Park, Jin Young
    Camargo, M. Constanza
    Lunet, Nuno
    Forman, David
    Soerjomataram, Isabelle
    [J]. GUT, 2020, 69 (05) : 823 - 829
  • [7] Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer
    Azuma, T
    Yamazaki, S
    Yamakawa, A
    Ohtani, M
    Muramatsu, A
    Suto, H
    Ito, Y
    Dojo, M
    Yamazaki, Y
    Kuriyama, M
    Keida, Y
    Higashi, H
    Hatakeyama, M
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2004, 189 (05) : 820 - 827
  • [8] Higher number of Helicobacter pylori CagA EPIYA C phosphorylation sites increases the risk of gastric cancer, but not duodenal ulcer
    Batista, Sergio A.
    Rocha, Gifone A.
    Rocha, Andreia M. C.
    Saraiva, Ivan E. B.
    Cabral, Monica M. D. A.
    Oliveira, Rodrigo C.
    Queiroz, Dulciene M. M.
    [J]. BMC MICROBIOLOGY, 2011, 11
  • [9] Identification of Helicobacter pylori and the evolution of an efficacious childhood vaccine to protect against gastritis and peptic ulcer disease
    Blanchard, Thomas G.
    Czinn, Steven J.
    [J]. PEDIATRIC RESEARCH, 2017, 81 (01) : 170 - 176
  • [10] Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon
    Brittan, M
    Hunt, T
    Jeffery, R
    Poulsom, R
    Forbes, SJ
    Hodivala-Dilke, K
    Goldman, J
    Alison, MR
    Wright, NA
    [J]. GUT, 2002, 50 (06) : 752 - 757