Synthesis, Crystal Structure and Biological Activity of 4-Amino-2,4-dihydro-5-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-3H-1,2,4-triazole-3-thione Schiff Base

被引：0

作者：

Wang Zi-Jian ^{[1
]}

Sun Xiao-Hong ^{[1
,2
]}

Liu Yuan-Fa ^{[3
]}

Chen Bang ^{[3
]}

Jin Ru-Yi ^{[2
]}

Shen Sheng-Qiang ^{[1
]}

Ma Hai-Xia ^{[2
]}

机构：

[1] NW Univ Xian, Chem Res Inst, Xian 710069, Peoples R China

[2] NW Univ Xian, Sch Chem Engn, Xian 710069, Peoples R China

[3] NW Univ Xian, Coll Chem & Mat Sci, Xian 710069, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2016年 / 35卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Schiff base; 1,2,4-triazole; pyrazole; synthesis; structure; biological activity; PYRAZOLE DERIVATIVES; 1,2,4-TRIAZOLE; ANTIBACTERIAL; INHIBITORS; DESIGN; AGENTS; COMPLEXES;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The target compound 1,2,4-triazole Schiff base containing pyrazole ring was synthesized by 4-amino-2,4-dihydro-5-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-3H-1,2,4-triazole-3-thione and 3,4,5-trimethoxy benzaldehyde. The structure was confirmed by IR, H-1 NMR, H RMS, elemental analysis and single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P (1) over bar with a = 7.8772(17), b = 8.2986(18), c = 15.392(3) angstrom, alpha = 93.360(4), beta = 94.609(4), gamma = 93.584(4)degrees, C18H22N6O3S, M-r = 402.47, V = 998.9(4) angstrom(3), Z = 2, F(000) = 422, D-c = 1.335 g/cm(3), mu = 0.194 mm(-1), the final R = 0.0533 and wR = 0.1329 for 3517 observed reflections with I > 2 sigma(1). The preliminary bioassay results indicate that the target compound has good fungicidal activity against Gibberlla nicotiancola in EC50 value and F. O. f.sp. niveum in EC95 value.

引用

页码：212 / 218

页数：7

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